Publications by authors named "Lucie Calmels"
Evaluation of an automated template-based treatment planning system for radiotherapy of anal, rectal and prostate cancer.
Tech Innov Patient Support Radiat Oncol
June 2022
Background And Purpose: The Ethos system has enabled online adaptive radiotherapy (oART) by implementing an automated treatment planning system (aTPS) for both intensity-modulated radiotherapy (IMRT) and volumetric modulated arc radiotherapy (VMAT) plan creation. The purpose of this study is to evaluate the quality of aTPS plans in the pelvic region.
Material And Methods: Sixty patients with anal (n = 20), rectal (n = 20) or prostate (n = 20) cancer were retrospectively re-planned with the aTPS.
Background And Purpose: Online adaptive radiotherapy (oART) potentially reduces the dose to organs at risk (OARs) as the planning target volume (PTV) margins are reduced compared to a non-adaptive approach (non-ART). This study evaluates the feasibility and dosimetric impact of cone-beam computed tomography (CBCT)-guided oART of urinary bladder cancer for the first patients treated, using patient-specific margins.
Materials And Methods: Sixteen consecutive patients with muscle-invasive bladder cancer received two or more (median = 23) fractions as oART, and remaining fractions as non-ART.
Purpose: The purpose of this study was to evaluate our 2 years' experience with single-isocenter, non-coplanar, volumetric modulated arc therapy (VMAT) for brain metastasis (BM) stereotactic radiosurgery (SRS).
Methods: A total of 202 patients treated with the VMAT SRS solution were analyzed retrospectively. Plan quality was assessed for 5 mm (120) and 2.
Background And Purpose: Studies have demonstrated the potential of online adaptive radiotherapy (oART). However, routine use has been limited due to resource demanding solutions. This study reports on experiences with oART in the pelvic region using a novel cone-beam computed tomography (CBCT)-based, artificial intelligence (AI)-driven solution.
View Article and Find Full Text PDFLow-energy X-rays induce Auger cascades by photoelectric absorption in iodine present in the DNA of cells labeled with 5-iodo-2'-deoxyuridine (IUdR). This photoactivation therapy results in enhanced cellular sensitivity to radiation which reaches its maximum with 50 keV photons. Synchrotron core facilities are the only way to generate such monochromatic beams.
View Article and Find Full Text PDFObjectives: The purposes of this study were to assess the reliability of parametric maps from dynamic contrast-enhanced ultrasound (DCE-US) to reflect the heterogeneous distribution of intratumoral vascularization and to predict the tissue features linked to vasculature. This study was designed to compare DCE-US parametric maps with histologic vascularity measurements.
Materials And Methods: Dynamic contrast-enhanced ultrasound was performed on 17 melanoma-bearing nude mice after a 0.
Article Synopsis
- This study explores the cardiac side effects of radiotherapy in breast cancer patients, particularly focusing on how it affects heart size and function over time.
- Researchers found evidence of cardiac hypertrophy (enlargement) in patients and identified specific fibrogenic signals associated with radiation-induced damage, as well as studying similar effects in mice models.
- Epac-1 was discovered to play a significant role in radiation-induced cardiac issues, particularly hypertrophy and amyloidosis, highlighting its potential as a therapeutic target.