Publications by authors named "Lucie Adoux"
Article Synopsis
- There is increasing interest in analyzing kidney biopsies through transcriptomic assessments to understand gene expression changes related to rejection.
- This study used next-generation sequencing (NGS) on RNA from 770 kidney biopsies to identify differentially expressed genes (DEGs) associated with antibody-mediated rejection (AMR) and T cell-mediated rejection (TCMR), revealing 603 and 1,186 new specific genes, respectively.
- Pathway analysis linked established panels to immunological processes in AMR and TCMR, while NGS uncovered novel transcripts that could inform future drug design and therapeutic strategies.
Article Synopsis
- Unintegrated HIV DNA makes up 20-35% of the total viral DNA in infected patients, with linear forms (unintegrated linear DNAs or ULDs) being crucial for integration and viral replication.
- The detection of ULDs is challenging due to the limitations of existing methods, which lack specificity and sensitivity.
- A new technology called DUSQ, combining linker-mediated PCR and next-generation sequencing, has been developed for ultra-sensitive quantification of ULDs and can track pre-integrative latency in HIV-1 infected patients, with potential applications for other rare DNA molecules.
Background: Nonalcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease, which is associated with features of metabolic syndrome. NAFLD may progress in a subset of patients into nonalcoholic steatohepatitis (NASH) with liver injury resulting ultimately in cirrhosis and potentially hepatocellular carcinoma. Today, there is no approved treatment for NASH due to, at least in part, the lack of preclinical models recapitulating features of human disease.
View Article and Find Full Text PDFBackground: Whole-genome sequencing (WGS) is becoming increasingly helpful to assist malaria control programmes. A major drawback of this approach is the large amount of human DNA compared to parasite DNA extracted from unprocessed whole blood. As red blood cells (RBCs) have a diameter of about 7-8 µm and exhibit some deformability, it was hypothesized that cheap and commercially available 5 µm filters might retain leukocytes but much less of Plasmodium falciparum-infected RBCs.
View Article and Find Full Text PDFObjectives: Group B Streptococcus (GBS) (Streptococcus agalactiae) is a pathogen of growing importance in adults. The objective of this study was to describe the features of invasive infections by GBS in non-pregnant adults.
Methods: GBS infections were reported to the national reference centre for streptococci.