Publications by authors named "Luciano Tartaglia"
Article Synopsis
- Anderson-Fabry disease (AFD) is a rare genetic disorder that leads to organ damage due to a lack of α-galactosidase A, causing harmful substances to accumulate in tissues, particularly affecting the heart and kidneys.
- * Researchers conducted a study using cardiovascular magnetic resonance (CMR) and T1 mapping to evaluate kidney involvement in 19 AFD patients compared to a control group without kidney disease.
- * The findings indicated a positive correlation between heart and kidney T1 values in AFD patients, and a negative correlation in kidney T1 values between AFD and control patients, suggesting kidney damage from microvascular issues in AFD.
Background: Fabry disease is a rare progressive X-linked lysosomal storage disease caused by mutations in the GLA gene that encodes α-galactosidase A. Agalsidase beta is a recombinant enzyme replacement therapy authorized in Europe at a standard dose of 1.0 mg/kg intravenously every other week at an initial infusion rate of ≤ 0.
View Article and Find Full Text PDFBackground: Hepatitis B virus (HBV) infections are a matter of concern in hemodialysis units; occult HBV infections (serum HBsAg negative but HBV DNA positive) were demonstrated in this setting, and this involves further concerns regarding possible transmission and pathogenic consequences. This study aimed to investigate the prevalence and correlates of occult HBV infection in a group of patients with reference to a single hemodialysis unit in southeastern Italy.
Methods: We analyzed HBV serology and DNA (using a qualitative nested PCR) in 128 HBsAg-negative hemodialysis patients, and correlated the results obtained, with sex, age, hemodialysis duration and HCV seropositivity.