Publications by authors named "Luciano Rodriguez Gomez"
Article Synopsis
- The PERISCOPE Phase I clinical trial assessed the safety of PeriCord, a tissue graft made from decellularised pericardial matrix and umbilical cord mesenchymal cells, in patients undergoing surgical revascularization after non-acute myocardial infarction.
- In the trial, seven patients received PeriCord and demonstrated no adverse effects during the one-year follow-up, although there were no significant changes in overall quality of life or cardiac function compared to controls.
- The study highlighted PeriCord's immunomodulatory effects, specifically in influencing the behavior of circulating monocytes towards a repair-promoting state, indicating potential for further exploration in treating inflammation-related conditions.
Article Synopsis
- - This study focused on scaling up a small cardiac tissue engineering construct, known as PeriCord, into a human-size therapeutic product to aid post-heart attack recovery in patients.
- - PeriCord is made from a decellularised pericardial matrix and contains human stem cells, with tests confirming its quality and safety before it was implanted in a patient with significant heart damage.
- - The first implantation in a 63-year-old male showed promising results, with no adverse reactions or need for immunosuppression, and a notable reduction in the heart scar observed after three months.
In this article, we will discuss the main aspects to be considered to define standard operation procedures (SOPs) for the creation of an induced pluripotent stem cell (iPSC) bank using cord blood (CB)-or similar cell type-bank guidelines for clinical aims. To do this, we adapt the pre-existing SOP for CB banking that can be complementary for iPSCs. Some aspects of iPSC manufacturing and the particular nature of these cells call for special attention, such as the potential multiple applications of the cells, proper explanation to the donor for consent of use, the genomic stability and the risk of genetic privacy disclosure.
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