Temporal rearrangement of pre-ictal PTZ induced spike discharges by low frequency electrical stimulation to the amygdaloid complex.

Background: Epilepsy is a common neurological disease affecting over 40 million people worldwide. The foremost important challenge of epileptologists has been to control and predict the recurrent and spontaneous seizures of epileptic patients. The application of low frequency electrical stimulation (LFS) in deep brain structures has shown promising results in seizure control.