Immunogenicity of antigens from outer membrane vesicles of associated with bilayer fragment of dioctadecyldimethylammonium in Swiss adult mice.

Purpose: In the present study, meningococcal serogroup B outer membrane vesicles (OMVs) were associated with bilayer fragments of a cationic lipid, dioctadecyldimethylammonium (DDA-BF), used as adjuvant, in an antigenic preparation tested in adult female outbred mice. This adjuvant was compared to the traditional adjuvant aluminum hydroxide.

Materials And Methods: The potential in generating humoral response was evaluated by enzyme-linked immunosorbent assay (ELISA).