Publications by authors named "Luciana Silvestri"
Calcif Tissue Int
May 2024
Article Synopsis
- Pre-proenkephalin 1 (Penk1) is a pro-neuropeptide linked to analgesic properties and was found to be significantly downregulated in osteoblasts under microgravity conditions, as well as in bone from various models of mechanical unloading.
- Despite high expression levels in mouse bone, global deletion of Penk1 did not produce noticeable changes in bone metabolism, indicating that its absence does not drastically alter bone structure.
- In vitro studies showed that inhibiting Penk1 in mature osteoblasts led to changes in gene expression related to bone metabolism, and primary osteoblasts from Penk1 knockout mice exhibited reduced differentiation and metabolic activity, demonstrating Penk1's role in bone response to mechanical changes
