Exposure of suckling rats to hexavalent chromium (CrVI) alters bone formation at the base of the alveolus causing a delay in tooth eruption.

Objectives: Hexavalent chromium (CrVI)-exposure of suckling rats has been shown to delay tooth eruption. However, the effects of CrVI-exposure on bone formation at the base of the alveolus, which provides a motive force for tooth eruption in the early stages of the process, remain unknown. The present work sought to evaluate the effect of CrVI-exposure on bone formation at the base of the alveolus during the intraosseous stage of tooth eruption in suckling rats, using histomorphometric and immunohistochemical studies.

Alterations in odontogenesis and tooth eruption resulting from exposure to hexavalent chromium in suckling animals.

Background: Heavy metals including Cr VI are present in inadequately treated effluents that contaminate drinking water. Hence, Cr VI exposure can affect children through intake of breast milk from an exposed mother or bottle-feeding formula prepared with contaminated water. To date, there are no reports on the effects of Cr VI exposure on tooth formation processes concomitant to tooth eruption.

Long term bone alterations in aged rats suffering type 1 diabetes.

Unlabelled: Increasing duration of type 1 diabetes mellitus alters bone metabolism. Clinical studies and experimental studies in long bones of rats with experimentally induced diabetes have reported a decrease in bone density. Few studies have explored this diabetes related alteration in the maxillae.