Effect of nitric oxide inhibitor and donor substances on the inflammatory process caused by endodontic irrigants.

Unlabelled: Nitric oxide (NO) has been considered a key molecule in inflammation.

Objective: The aim of this study was to evaluate the effect of treatment with L-NAME and sodium nitroprussiate, substances that inhibit and release NO, respectively, on tissue tolerance to endodontic irrigants.

Material And Methods: The vital dye exudation method was used in a rat subcutaneous tissue model.