Publications by authors named "Luciana M Canavieira"
Chem Biol Drug Des
November 2017
Article Synopsis
- Inhibition of mushroom tyrosinase was effectively achieved using synthetic dihydropyrano[3,2-b]chromenediones, particularly DHPC04, which showed strong activity comparable to the standard inhibitor kojic acid.
- Kinetic studies indicated that these compounds act as competitive inhibitors at the L-DOPA binding site of the enzyme.
- Molecular modeling further revealed key insights into how these compounds interact with the copper active site of tyrosinase.
