Publications by authors named "Luciana M B Carlos"
Several biomarkers have been evaluated as predictors of severity or in directing the treatment of COVID-19, however there are no conclusive results. In this study, we evaluated serum levels of cytokines, chemokines, and cell growth factors in association with the pathobiology of mild to moderate SARS-CoV-2 infection. Serum levels of SARS-CoV-2 infected patients (n = 113) and flu symptoms individuals negative for SARS-CoV-2 (n = 58), tested by the RT-qPCR test-nasal swab were compared to healthy controls (n = 53).
View Article and Find Full Text PDFSARS-CoV-2 serologic surveys estimate the proportion of the population with antibodies against historical variants, which nears 100% in many settings. New approaches are required to fully exploit serosurvey data. Using a SARS-CoV-2 anti-Spike (S) protein chemiluminescent microparticle assay, we attained a semi-quantitative measurement of population IgG titers in serial cross-sectional monthly samples of blood donations across seven Brazilian state capitals (March 2021−November 2021).
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the complex regional differences in COVID-19 spread across Brazil by analyzing IgG antibody seroprevalence from blood donations in 8 major cities from March 2020 to March 2021.
- Results show that SARS-CoV-2 attack rates varied significantly among cities, ranging from 19.3% in Curitiba to 75% in Manaus, with notable demographic differences in infection rates and fatality.
- The findings emphasize the importance of blood donor serosurveillance for understanding the epidemic's progress and reveal how health system challenges exacerbated infection outcomes, particularly during the emergence of the Gamma variant.