Publications by authors named "Luciana Dos Santos Freitas"
Article Synopsis
- A new cyclic natural compound, formed from succinic acid and two alanine amino acid units, was isolated from honey extract and its structure was determined through various NMR techniques.
- In cell culture studies, this compound reduced the number of tachyzoites (a parasitic stage) by 40-56% within 24 hours, and 25-50% over 72 hours, in a dose-dependent manner.
- The compound showed no toxicity to glial cells at concentrations up to 25 µg/mL and was associated with increased nitric oxide levels, suggesting a potential impact on DNA synthesis and protein production in affected cells.
In the central nervous system, astrocytes and microglia contribute to homeostasis, regulating the immune response to infectious agents. is an obligate intracellular protozoan that infects different animal species and it is encysted in their nervous tissue while triggering an immune response modulated by glia. This study aimed to evaluate the infection of primary cultures of rat glial cells by through the catabolites of tryptophan, the expression of inflammatory mediators and the integrity of neural tissue.
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