Detecting dissonance in clinical and research workflow for translational psychiatric registries.

Background: The interplay between the workflow for clinical tasks and research data collection is often overlooked, ultimately making it ineffective.

Questions/purposes: To the best of our knowledge, no previous studies have developed standards that allow for the comparison of workflow models derived from clinical and research tasks toward the improvement of data collection processes.

Methods: In this study we used the term dissonance for the occurrences where there was a discord between clinical and research workflows.

A system dynamics analysis determining willingness to wait and pay for the implementation of data standards in clinical research.

Background: Industry standards provide rigorous descriptions of required data presentation, with the aim of ensuring compatibility across different clinical studies. However despite their crucial importance, these standards are often not used as expected in the development of clinical research. The reasons for this lack of compliance could be related to the high cost and time-intensive nature of the process of data standards implementation.

So different, yet so similar: meta-analysis and policy modeling of willingness to participate in clinical trials among Brazilians and Indians.

Background: With the global expansion of clinical trials and the expectations of the rise of the emerging economies known as BRICs (Brazil, Russia, India and China), the understanding of factors that affect the willingness to participate in clinical trials of patients from those countries assumes a central role in the future of health research.

Methods: We conducted a systematic review and meta-analysis (SRMA) of willingness to participate in clinical trials among Brazilian patients and then we compared it with Indian patients (with results of another SRMA previously conducted by our group) through a system dynamics model.

Results: Five studies were included in the SRMA of Brazilian patients.

Achieving high research reporting quality through the use of computational ontologies.

Systematic reviews and meta-analyses constitute one of the central pillars of evidence-based medicine. However, clinical trials are poorly reported which delays meta-analyses and consequently the translation of clinical research findings to clinical practice. We propose a Center of Excellence in Research Reporting in Neurosurgery (CERR-N) and the creation of a clinically significant computational ontology to encode Randomized Controlled Trials (RCT) studies in neurosurgery.

Computational ontologies in orthopaedic surgery.

Information Technology (IT) plays an important role in storing and collating the vast amounts of healthcare data. However, analyzing and integrating this data to extract useful information is difficult due to the heterogeneous, siloed, disparate, and unstructured nature of the data. WHERE ARE WE NOW?: Attempts to standardize data reporting by establishing reporting standards, checklists and guidelines have not been optimal.

Qualitative analysis of the interdisciplinary interaction between data analysis specialists and novice clinical researchers.

Background: The inherent complexity of statistical methods and clinical phenomena compel researchers with diverse domains of expertise to work in interdisciplinary teams, where none of them have a complete knowledge in their counterpart's field. As a result, knowledge exchange may often be characterized by miscommunication leading to misinterpretation, ultimately resulting in errors in research and even clinical practice. Though communication has a central role in interdisciplinary collaboration and since miscommunication can have a negative impact on research processes, to the best of our knowledge, no study has yet explored how data analysis specialists and clinical researchers communicate over time.

Involvement of histamine receptors in the acquisition of inhibitory avoidance in Carassius auratus.

This study investigated the involvement of H(1) and H(2) histaminegic receptors on the acquisition of a new task in Carassius auratus by using an inhibitory avoidance paradigm in which the animals had to learn to avoid an aversive stimulus. Before training, the fish received injections of H(2) antagonist zolantidine at a dose of 20 mg/kg, or H(1) antagonist chlorpheniramine at a dose of 4 or 16 mg/kg. Control animals were injected with distilled water.