Publications by authors named "Luciana Castro Garcia Landeiro"
The burden of systemic therapy administration route in treating HER2-positive breast cancer (for patients, healthcare professionals, and healthcare system): a systematic literature review.
Front Pharmacol
August 2024
Introduction: Breast cancer (BC) is one of the leading causes of cancer and is the first cause of death from malignant tumors among women worldwide. New cancer therapies receive regulatory approval yearly and to avoid health disparities in society, the health systems are challenged to adapt their infrastructure, methodologies, and reimbursement policies to allow broad access to these treatments. In addition, listening to patients' voices about their therapy preferences is essential.
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- Breast cancer is the top cause of cancer-related deaths among women globally, yet there's a lack of research on metastatic breast cancer (MBC) in low- and middle-income countries, particularly regarding the genomic features of Brazilian patients.
- This study analyzed tumor samples from 328 Brazilian women with estrogen receptor-positive (ER+)/HER2-negative MBC to assess mutations in the PI3K-AKT pathway and other key genetic drivers using advanced sequencing techniques from 2020 to 2023.
- Findings indicated a 39.3% mutation prevalence in the PI3K-AKT pathway, with older patients (over 50) showing increased mutation rates and 6.1% of samples harboring mutations in the PTEN gene, especially in
Chemotherapy-induced alopecia (CIA) is a challenge in the management of cancer patients. Scalp cooling (SC) leads to reduction in CIA, however it is associated with significant adverse events, leading to 3-13% discontinuation rates. This pilot study evaluated the role of Electric Hand Warmers (EHW) on thermal (TC), sensorial (SCo) and general comfort (GC) in patients with breast cancer (BC) undergoing chemotherapy and SC to reduce CIA.
View Article and Find Full Text PDFObjective: Cancer imposes a profound burden on low- and middle-income countries where 65% of the global cancer deaths occurred in 2020. The objective of the present review was to describe female cancer epidemiology in Brazil, barriers to prevention, screening, and treatment, and to propose strategies to a better control.
Methods: For the process of literature search and scientific acquisition, we have utilized the terms "female cancer" AND "breast cancer," AND "cervical cancer" AND "endometrial cancer" AND "ovarian cancer" AND "Brazil" in PubMed.
Objective: This article aims to alert health professionals for cancer screening in the face of the possibility of new waves of disease.
Methods: A narrative review was conducted through a search in MEDLINE, Lilacs, Chinese Biomedical Literature Database, and international medical societies publications.
Results: Breast cancer: in high-risk patients (confirmed familial cancer syndrome or with high-risk tools scores), clinicians should act according to usual recommendations; in average-risk individuals, consider screening with mammography with a longer time span (maximum of two years).