Publications by authors named "Luciana Avila Quevedo"

Article Synopsis
  • Childhood trauma negatively affects mental health and can be passed down to future generations, impacting the emotional and behavioral issues of children.
  • The study analyzed 310 preschool-aged children to see how maternal childhood trauma interacted with genetic factors, specifically the COMT ValMet variant, and assessed behavioral problems using established questionnaires.
  • Results showed that while maternal trauma generally increases behavioral issues in children, those with the Val/Met genotype are less prone to certain problems compared to those with other genetic variants, highlighting the importance of both trauma and genetics in child development.
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  • The study explores how cortisol and oxytocin levels change during pregnancy, focusing on a cohort of pregnant women in Southern Brazil.
  • Researchers found that cortisol levels increase exponentially as pregnancy progresses, starting at an average of 44.2 μg/dl in the first week and rising by about 2% weekly.
  • In contrast, oxytocin levels did not show significant changes throughout the studied period, indicating a need for further research to understand its variability during pregnancy.
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  • Defense mechanisms are psychological strategies people use to protect their sense of self, and in OCD, compulsive behaviors can be viewed as these mechanisms.
  • A study with 92 OCD patients evaluated the effectiveness of brief cognitive behavioral therapy by measuring changes in defense mechanisms at three different time points.
  • The results indicated a consistent improvement in mature defense mechanisms during therapy, suggesting patients were developing healthier ways to handle conflicts, while no significant changes were observed in neurotic or immature mechanisms.
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  • MicroRNAs (miRNAs), such as hsa-miR-423-5p, play a significant role in regulating gene expression and are important for various biological processes, especially during pregnancy when maternal health impacts infant development.
  • A longitudinal study conducted in southern Brazil examined the relationship between maternal levels of hsa-miR-423-5p in early pregnancy and cognitive development in infants at 90 days old, using blood samples and cognitive assessments.
  • Results showed that higher maternal levels of miR-423-5p correlate with better cognitive abilities in infants, suggesting this miRNA could serve as a prenatal biomarker for predicting and potentially improving child neurocognitive development through early interventions.
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Background: Exposure and introduction to digital media, especially in children, are a current cause for concern. The negative links associated with early screen exposure are extensive.

Aims: To evaluate the association between the time of exposure to a screen in children at 18 months of age and cognitive development in a population-based sample in Southern Brazil.

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Article Synopsis
  • * It focused on two specific genetic variants: OXTR rs2254298, which was identified as a risk factor for both ADHD and anxiety, and CD38 rs6449182, associated with ADHD risk.
  • * The findings offer insights into the genetic factors influencing developmental and behavioral disorders, highlighting the need for further research to better understand their underlying neurobiology in children.
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  • The study investigates the link between Generalized Anxiety Disorder (GAD), the severity of depression, and stressors among pregnant women in Brazil during their first and second trimesters.
  • Women with varying levels of depressive symptoms had significantly increased odds of experiencing GAD, with severe symptoms leading to the highest risk.
  • The research suggests the importance of implementing prevention strategies to enhance maternal mental health, which can positively impact infant development in the long run.
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Background: The discussion on the safety of thimerosal-containing vaccines (TCVs) and their impact on child development it́s very relevant.

Methods: This is a cohort study with mother-child dyads who received prenatal care in the Unified Health System. The domains of motor, cognitive and language development were evaluated in children between 24 and 36 months of age.

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Objectives: This study aimed to investigate the association between child maltreatment and depressive symptomatology during gestation in adolescents.

Methods: This was a cross-sectional study with pregnant adolescents aged 12 to 19 years. Data were collected with the Beck Depression Inventory, Childhood Trauma Questionnaire, and Mini International Neuropsychiatric Interview.

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A large number of children of depressed mothers have one or more mental disorders. This study aimed to evaluate the impact of maternal depression on the mental health of 4-5-year-old children of adolescent mothers, according to the hypotheses generated from the model of accumulation. Between October 2009 and March 2011, all pregnant adolescents who received prenatal care from the public health system in Pelotas (southern Brazil) were invited to participate in the study and have been prospectively followed.

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The present study aimed to investigate the effectiveness of a psychoeducational intervention on caregivers of patients assisted by the Center for Psychosocial Health Care (CPHC) focusing on the patient's psychopathology. This was a randomized clinical trial with 130 caregivers with higher mean burden scores assessed using the Zarit Burden Interview Scale (ZBI) (66 caregivers in the intervention group and 64 in the control group). The intervention included six home visits of psychoeducational interventions according to each mental disorder identified in the CPHC records.

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Aim: To investigate the relationship between maternal depression and childhood caries in a cohort of adolescent mothers.

Methods: This cross-sectional study nested in a cohort evaluated a sample of 538 mother/child dyads. When the children were 24-36 months of age, data regarding oral health from children and mothers were collected by clinical dental examination.

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Burnout syndrome (BOS) is the result of chronic stress at work, and is characterized by emotional exhaustion (EE), depersonalization (DP), and low professional accomplishment. Anesthesiologyis a stressful profession. The aim of this study was to assess the prevalence of burnout as well as the sociodemographic and working characteristics associated with this syndrome's emotional factors, in anesthesiologists from Southern Brazil.

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Introduction: Depression during pregnancy in adolescents is increasing significantly. However, instruments for early depression screening during prenatal care are scarce. Faced this fact, the objective of this research is to identify the best cutoff points for the Edinburgh Postnatal Depression Scale (EPDS) and Beck Depression Inventory (BDI) in a sample of pregnant adolescents.

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Background: Studies show high comorbidity between anxiety disorder and depression. Little is known regarding how anxiety symptoms affect prognosis in depression treatment, suggesting the importance of studying the impact of anxiety symptoms in the treatment of depression. We evaluated the impact of anxiety symptoms in the remission of depressive symptoms after brief psychotherapies for depression.

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Background: Early adverse experiences are associated with increased risk of developing psychiatric disorders, although little is known about the neurobiological mediators involved. The mechanisms by which early environmental influences may mediate vulnerability in the development of offspring await further investigation. The present study correlated the NGF, BDNF, IL-6 and cortisol levels of mothers with postpartum affective disorders (PPAD) with infant development.

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Unlabelled: Postpartum depression (PPD) is the most common psychiatric complication observed in women after they give birth. Some women are particularly sensitive to hormonal changes, starting in early menarche, thus increasing their vulnerability to psychological stressing agents that are triggered by environmental and physiological factors throughout their lives. Decreased serum brain-derived neurotrophic factor (BDNF) levels have been associated to different neuropsychiatric conditions and BDNF has been considered as a candidate marker for such dysfunctions.

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