Mass Spectrometry Metabolomics Approach Reveals Anti-Trichomonas vaginalis Scaffolds from Marine Fungi.

Trichomoniasis is the most common non-viral sexually transmitted infection (STI) in the world caused by Trichomonas vaginalis. Failures in the treatment with the 5-nitroimidazole class including parasite resistance to metronidazole elicit new alternatives. Marine natural products are sources of several relevant molecules, presenting a variety of metabolites with numerous biological activities.

Polyketides from marine-derived Aspergillus welwitschiae inhibit Staphylococcus aureus virulence factors and potentiate vancomycin antibacterial activity in vivo.

Staphylococcus aureus, a major cause of nosocomial and community associated infections, is becoming increasingly resistant to antibiotics. S. aureus infections are frequently biofilm-associated, and a diverse spectrum of virulence factors are determinant in the pathogenicity, which can be an interesting target resulting in less selective pressure for bacterial resistance.