[2.2]Paracyclophane Derivatives as Building Blocks for Coordination Polymers.

Several new di- and tetracarboxylic [2.2]paracyclophane derivatives were obtained via Suzuki coupling between the appropriately brominated [2.2]paracyclophanes and 4-(methoxycarbonyl)phenylboronic acid.

Mesitylene Tribenzoic Acid as a Linker for Novel Zn/Cd Metal-Organic Frameworks.

Three new Metal-Organic Frameworks, containing mesitylene tribenzoic acid as a linker and zinc () or cadmium as metals (,), were synthesized through solvothermal reactions, using DMF/ethanol/water as solvents, at temperatures of 80 °C (structures and ) and 120 °C (structure ). Following single-crystal X-ray diffraction, it was found that and crystallize in the 2/ and C2/ space groups and form 2D networks, while crystallizes in the 2 space group, forming a 3D network. All three frameworks, upon heating, were found to be stable up to 350 °C.

Nitrogen-Based Linkers with a Mesitylene Core: Synthesis and Characterization.

Mesitylene was used as a core in seven new tritopic nitrogen containing linkers. Three of the linkers, each containing three nitrile groups, were obtained through Suzuki, Sonogashira and Heck-type coupling reactions. Next, these were converted to tetrazol-5- moieties by the cycloaddition of sodium azide to the nitrile functionalities.

An Approach to Paracyclophane-Based Tetrathiafulvalenes: Synthesis and Characterization of a [2.2]Paracyclophane 1,3-Dithia-2-Thione.

The synthesis of paracyclophane-based tetrathiafulvalene precursors is described in the context of the importance of these compounds in the field of material chemistry. bis(1,3-dithia-2-thione) was synthesized via the corresponding 1,3-dithiol-2-ylium salt. The latter was obtained by a synthetic procedure that involves 4,15-bis(acetyl)[2.

New Microporous Lanthanide Organic Frameworks. Synthesis, Structure, Luminescence, Sorption, and Catalytic Acylation of 2-Naphthol.

New metal-organic frameworks (MOF) with lanthanum(III), cerium(III), neodymium(III), europium(III), gadolinium(III), dysprosium(III), and holmium(III)] and the ligand precursor tris(-carboxyphenyl)--trimethylbenzene (HL) were synthesized under solvothermal conditions. Single crystal x-ray analysis confirmed the formation of three-dimensional frameworks of [LnL(HO)]·xDMF·yHO for Ln = La, Ce, and Nd. From the nitrogen sorption experiments, the compounds showed permanent porosity with Brunauer-Emmett-Teller (BET) surface areas of about 400 m/g, and thermal stability up to 500 °C.

The Cytotoxic Properties of Some Tricyclic 1,3-Dithiolium Flavonoids.

Background: Due to the emergence of multidrug resistant microorganisms, new classes of antibiotics are needed. In this paper, we present the cytotoxic effects of five tricyclic flavonoids, one of which was previously identified as a potent antimicrobial agent.

Methods: All five derivatives were tested against human HOS and MCF7 cancer cell lines using a wound scratch assay.

Aqueous Dispersion of Single-Walled Carbon Nanotubes Using Tetra-Phenyl Bimesitylene Derivative via Noncovalent Modification and Improved Antimicrobial Activity.

Tetra-arylbimesityl derivative containing carboxylic groups have successfully been utilized in dispersing single-walled carbon nanotubes (SWNTs) in aqueous solutions through sonication and centrifugation procedures. The dispersion process and the characterization of final stabilized SWNTs were accomplished using analytical techniques, providing sufficient evidences on the preparation of the dispersed SWNTs in water. All the prepared SWNT water dispersions were evaluated for antimicrobial activity against three different reference strains namely and , and have shown considerable selective activity against the Gram-positive strain .

A novel synthetic flavonoid with potent antibacterial properties: In vitro activity and proposed mode of action.

The emergence of pathogenic multidrug-resistant bacteria demands new approaches in finding effective antibacterial agents. Synthetic flavonoids could be a reliable solution due to their important antimicrobial activity. We report here the potent in vitro antibacterial activity of ClCl-flav-a novel synthetic tricyclic flavonoid.

[2.2]Paracyclophane-Bis(triazole) Systems: Synthesis and Photochemical Behavior.

Mono-, pseudo-gem, and pseudo-para ethynylcyclophanes and bis(azides) have been employed as addition partners in CuAAC reactions to design and build complex extended molecular scaffolds. The reactivity of the resulting triazoles was investigated under photochemical conditions. A variety of newly substituted [2.

Antibacterial structure-activity relationship studies of several tricyclic sulfur-containing flavonoids.

A structure-activity relationship study concerning the antibacterial properties of several halogen-substituted tricyclic sulfur-containing flavonoids has been performed. The compounds have been synthesized by cyclocondensation of the corresponding 3-dithiocarbamic flavanones under acidic conditions. The influence of different halogen substituents on the antibacterial properties has been tested against Staphylococcus aureus and Escherichia coli.

The influence of halogen substituents on the biological properties of sulfur-containing flavonoids.

A series of halogen-substituted tricyclic flavonoids containing a 1,3-dithiol-2-ylium moiety has been synthesized from the corresponding 3-dithiocarbamic flavanones. The influence of halogen substituents on the antibacterial properties of the tricyclic flavonoids has been investigated against Staphylococcus aureus and Escherichia coli. On going from fluorine to iodine, these compounds exhibit good to excellent inhibitory properties against both Gram-positive and Gram-negative pathogens.

[2.2]Paracyclophane derivatives containing tetrathiafulvalene moieties.

The synthesis of [2.2]paracyclophane derivatives containing tetrathiafulvalene units has been accomplished by the coupling reaction of 4-([2.2]paracyclophan-4-yl)-1,3-dithiol-2-thione in the presence of trimethylphosphite.

The antibacterial properties of sulfur containing flavonoids.

Some dithiocarbamic esters bearing a flavanone backbone, as well as their corresponding 1,3-dithiolium salts were tested against Staphylococcus aureus and Escherichia coli. The 1,3-dithiolium tricyclic flavonoids display good inhibitory properties against both Gram-positive and Gram-negative pathogens.

4-Bromo-2-[5-methyl-2-(morpholin-4-yl)-1,3-thia-zol-4-yl]phenol.

In the title compound, C14H15BrN2O2S, synthesized by the reaction of the corresponding phenacyl thio-cyanate with morpholine, the dihedral angle between the 1,3-thia-zole ring and the phenolic substituent ring is 23.46 (10)° as a result of the steric influence of the ortho-methyl group on the thia-zole ring. A strong intra-molecular phenolic O-H⋯N hydrogen bond is present in the mol-ecule.

Tricyclic flavonoids with 1,3-dithiolium substructure.

The synthesis of new 3-dithiocarbamic flavonoids has been accomplished by the reaction of the corresponding 2-hydroxyaryl dithiocarbamates with aminals. These flavonoids were obtained as a mixture of diastereoisomers, the anti isomer being the major one. The heterocyclization of these compounds provided novel tricyclic flavonoids bearing a 1,3-dithiolium-2-yl ring fused at the 3,4-carbon positions of the benzopyran moiety.