Publications by authors named "Lucia Valiente"
Inflammation is a central pathogenic feature of the acute respiratory distress syndrome (ARDS) in COVID-19. Previous pathologies such as diabetes, autoimmune or cardiovascular diseases become risk factors for the severe hyperinflammatory syndrome. A common feature among these risk factors is the subclinical presence of cellular stress, a finding that has gained attention after the discovery that BiP (GRP78), a master regulator of stress, participates in the SARS-CoV-2 recognition.
View Article and Find Full Text PDFArticle Synopsis
- Neurologic impairment can last for months after severe COVID-19 infection due to ongoing inflammation.
- A study analyzed cognitive functions in 152 patients recovering from severe SARS-CoV-2 infection, finding significant issues with memory, executive functions, and attention, alongside elevated anxiety and depression rates.
- The study also identified increased levels of certain plasma biomarkers in these patients, raising concerns about potential long-term cognitive effects or the risk of neurodegenerative diseases.
Objective: To prove that 7-day courses of antibiotics for bloodstream infections caused by members of the Enterobacterales (eBSIs) allow a reduction in patients' exposure to antibiotics while achieving clinical outcomes similar to those of 14-day schemes.
Methods: A randomized trial was performed. Adult patients developing eBSI with appropriate source control were assigned to 7 or 14 days of treatment, and followed 28 days after treatment cessation; treatments could be resumed whenever necessary.