Influence of the phonon-bottleneck effect and low-energy vibrational modes on the slow spin-phonon relaxation in Kramers-ions-based Cu(II) and Co(II) complexes with 4-amino-3,5-bis-(pyridin-2-yl)-1,2,4-triazole and dicyanamide.

Two new complexes, bis-[4-amino-3,5-bis-(pyridin-2-yl)-1,2,4-triazole-κ,]bis-(dicyanamide-κ)copper(II), [Cu(abpt)(dca)] (1) and bis-[4-amino-3,5-bis-(pyridin-2-yl)-1,2,4-triazole-κ,]bis-(dicyanamide-κ)cobalt(II), [Co(abpt)(dca)] (2), have been prepared and magneto-structurally characterised. Single crystal studies of both complexes have shown that their crystal structures are molecular, in which the central atoms are six-coordinated in the form of a distorted octahedron by two bidentate abpt and two monodentate dca ligands. Even if both complexes have the same composition and crystallize in the same 1̄ space group, they are not isostructural.

In vivo study of light-driven naproxen release from gated mesoporous silica drug delivery system.

A drug delivery system based on mesoporous particles MCM-41 was post-synthetically modified by photo-sensitive ligand, methyl-(2E)-3-(4-(triethoxysilyl)-propoxyphenyl)-2-propenoate (CA) and the pores of MCM-41 particles were loaded with Naproxen sodium salt (NAP). The CA was used as a photoactive molecule that can undergo a reversible photo-dimerization by [2π + 2π] cycloaddition when irradiated with UV light of specific wavelengths. Thus, it has a function of gate-keeper that is responsible for opening/closing the pores and minimizing premature release of NAP.

Mesoporous Silica as a Drug Delivery System for Naproxen: Influence of Surface Functionalization.

In this work we describe the relationship between surface modification of hexagonally ordered mesoporous silica SBA-15 and loading/release characteristics of nonsteroidal anti-inflammatory drug (NSAID) naproxen. Mesoporous silica (MPS) was modified with 3-aminopropyl, phenyl and cyclohexyl groups by grafting method. Naproxen was adsorbed into pores of the prepared MPS from ethanol solution using a solvent evaporation method.

Doxorobicin as cargo in a redox-responsive drug delivery system capped with water dispersible ZnS nanoparticles.

In this work, we have prepared and investigated a redox-responsive drug delivery system (DDS) based on a porous carrier. Doxorubicin (DOX), a chemotherapy medication for treatment of different kinds of cancer, was used as a model drug in the study. DOX was loaded in ordered hexagonal mesoporous silica SBA-15, a nanoporous material with good biocompatibility, stability, large pore size and specific surface area ( = 908 m g, = 0.

A Study of 5-Fluorouracil Desorption from Mesoporous Silica by RP-UHPLC.

In cancer treatment, the safe delivery of the drug to the target tissue is an important task. 5-fluorouracil (5-FU), the well-known anticancer drug, was encapsulated into the pores of unmodified mesoporous silica SBA-15, as well as silica modified with 3-aminopropyl and cyclohexyl groups. The drug release studies were performed in two different media, in a simulated gastric fluid (pH = 2) and in a simulated body fluid (pH = 7) by RP-UHPLC.

Low-dimensional compounds containing cyanido groups. Part XXXV. Structure, spectral, thermal and magnetic properties of a binuclear Cu-biquinoline complex with bridging and terminal dicyanamide ligands.

From the system CuCl-biq-NaN(CN) (biq is 2,2'-biquinoline), the binuclear molecular complex bis(μ-dicyanamido-κN:N)bis[(2,2'-biquinoline-κN,N')(dicyanamido-κN)copper(II)], [Cu(CN)(CHN)] or [Cu(biq)(dca)(μ-dca)] (1) [dca is dicyanamide, N(CN)] was isolated and characterized by crystal structure analysis, and spectral, thermal and magnetic measurements. IR spectroscopy confirmed the presence of the biq and dca ligands in 1. Its solid-state structure consists of discrete centrosymmetric binuclear copper(II) units with double end-to-end dca bridges.

A Cu complex with an carbamoylcyanonitrosomethanide ligand formed in situ by the nucleophilic addition of water to dicyanonitrosomethanide: structure, spectral and magnetic properties.

The complex (2,2'-biquinoline-κN,N')(carbamoylcyanonitrosomethanide-κN,O)chloridocopper(II) acetonitrile monosolvate, [Cu(CHNO)Cl(CHN)]·CHCN or [Cu(ccnm)Cl(biq)]·acn (acn is acetonitrile, biq is 2,2'-biquinoline and ccnm is carbamoylcyanonitrosomethanide), (I), was prepared as a result of nucleophilic addition of water to the dicyanonitrosomethanide ion in the presence of Cu and biq. IR spectroscopy confirmed the presence of ccnm, biq and acn in (I). The solid-state structure consists of the neutral complex containing ccnm and biq ligands, coordinated to the Cu atom in a bidendate chelating manner, and a chloride ligand, resulting in a distorted tetragonal pyramidal coordination of Cu.

Slow magnetic relaxation in octahedral cobalt(II) field-induced single-ion magnet with positive axial and large rhombic anisotropy.

Pseudooctahedral mononuclear cobat(II) complex [Co(abpt)2(tcm)2] (1), where abpt = 4-amino-3,5-bis(2-pyridyl)-1,2,4-triazole and tcm = tricyanomethanide anion, shows field-induced slow relaxation of magnetization with U = 86.2 K and large axial and rhombic single-ion zero-field-splitting parameters, D = +48(2) cm(-1) and E/D = 0.27(2) (D = +53.

Low-dimensional compounds containing cyanide groups. XXV. Synthesis, spectroscopic properties and crystal structures of two ionic iron(II) complexes with tricyanomethanide: tris(1,10-phenanthroline-κ(2)N,N')iron(II) bis(tricyanomethanide) and tris(2,2'-bipyridine-κ(2)N,N')iron(II) bis(tricyanomethanide) sesquihydrate.

Two new diamagnetic coordination compounds, [Fe(phen)3][C(CN)3]2, (I), and [Fe(bpy)3][C(CN)3]2·1.5H2O, (II), have been synthesized and characterized by single-crystal X-ray diffraction analysis, and IR and UV-Vis spectroscopy (phen is 1,10-phenanthroline, C12H8N2, and bpy is 2,2'-bipyridine, C10H8N2). Both compounds are ionic with distorted octahedral [Fe(phen)3](2+) or [Fe(bpy)3](2+) complex cations, with average Fe-N distances of 1.

Tris(5,6-dimethyl-1,10-phenanthroline-κ(2) N,N')iron(II) bis-(tricyano-methanide).

The title compound, [Fe(C14H12N2)3](C4N3)2, consists of one [Fe(dimephen)3](2+) complex cation (dimephen = 5,6-dimethyl-1,10-phenanthroline) and two uncoordinating tcm anions (tcm = tricyano-methanide). In the complex cation, the Fe(II) atom is coordinated by six N atoms from three chelating dimephen ligands at an average Fe-N distance of 1.963 (4) Å giving a distorted octa-hedral geometry.