Publications by authors named "Lucia Sancho Temino"
The nucleosome remodeling factor BPTF is required for the deployment of the MYC-driven transcriptional program. Deletion of one allele delays tumor progression in mouse models of pancreatic cancer and lymphoma. In neuroblastoma, MYCN cooperates with the transcriptional core regulatory circuitry (CRC).
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- * In a study involving transgenic mice lacking Hif-1a in innate RORγt cells, severe colitis was observed after infection, primarily due to reduced IL-22 production.
- * The research identified that IL-18, triggered by Toll-like receptor 2, boosts IL-22 in ILC3s through HIF-1α, demonstrating a key oxygen-independent mechanism important for immune defense during C. rodentium infections.
Article Synopsis
- Caspases are unique to animals, while metacaspases (MCAs) in plants are older and biochemically different molecules, with most research focusing on Arabidopsis and its nine MCAs.
- Researchers studied CrMCA-II, a type-II MCA from the chlorophyte Chlamydomonas, finding that it surprisingly dimerizes like caspases, and its activation corresponds with this dimerization.
- The deletion of CrMCA-II resulted in decreased heat tolerance and increased cell death in Chlamydomonas, but restoring CrMCA-II—either active or inactive—helped regain thermotolerance, linking its function to modulating plasma membrane fluidity rather than its proteolytic