Publications by authors named "Lucia Reseco"
Article Synopsis
- Salivary extracellular vesicles (EVs) are promising biomarkers due to how easy it is to collect saliva, but inconsistent EV isolation methods limit their clinical use.
- The study compared eight different EV isolation techniques, focusing on EV concentration, size, protein content, and purity, particularly examining the effects of age on these vesicles.
- Results indicated that magnetic bead immunocapture improved EV recovery, while some methods showed better protein concentration and purity, paving the way for using salivary EVs as biomarkers for diseases throughout different life stages.
Background: Aging is associated with declining protective immunity and persistent low-grade inflammatory responses, which significantly contribute to Alzheimer's disease (AD) pathogenesis. Detecting aging-related cerebral vulnerability associated with deterioration of the immune system requires from non-invasive biomarkers able to detect failures in the brain-immunity connection. Reduced levels of salivary lactoferrin (sLF), an iron-binding protein with immunomodulatory activity, have been related to AD diagnosis.
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