The Impact of Demographic and Socioeconomic Factors on Major Salivary Gland Cancer Survival.

Objective: This study aimed to investigate the impact of demographic and socioeconomic factors on survival in patients with major salivary gland malignancies.

Study Design: Population-based study using the Surveillance, Epidemiology, and End Results (SEER) cancer database.

Subject And Methods: The study cohort consisted of 10,735 men and women ages 20 and older who were diagnosed with major salivary gland carcinoma from 1973 to 2009.

Apolipoprotein E epsilon4 and age at onset of sporadic and familial Alzheimer disease in Caribbean Hispanics.

Background: The primary effect of the apolipoprotein E epsilon4 (APOE epsilon4) allele is on the age at onset of Alzheimer disease (AD).

Objective: To investigate whether the presence of the APOE epsilon4 allele can account for the earlier age at onset of familial AD (FAD) compared with sporadic AD (SAD).

Design: Population-based, case series ascertained in a prospective study of aging and dementia in Medicare recipients aged 65 years or older.

Bone mineral density in an outpatient population receiving enzyme-inducing antiepileptic drugs.

Antiepileptic drug (AED) use is identified as being associated with increased fracture risk. AEDs commonly associated with osteopathies are inducers of the hepatic cytochrome p450 enzyme system (EIAEDs). We performed a retrospective cross-sectional study assessing bone mineral density (BMD) in an adult outpatient population receiving EIAEDs.