Publications by authors named "Lucia Mad'arova"
Article Synopsis
- The text discusses the impact of pneumococcal conjugate vaccines (PCVs), specifically PCV10 and PCV13, on invasive pneumococcal disease (IPD) globally, highlighting how these vaccines have reduced the prevalence of disease caused by vaccine-type serotypes after extensive use.
- It describes the methodology of data collection from various surveillance sites, which aimed to evaluate IPD cases that occurred five years after the vaccines were implemented, focusing on different age groups for analysis.
- Findings indicate significant differences in serotype distribution between PCV10 and PCV13 sites; notably, certain serotypes, such as 19A and serotype 3, were prevalent in specific age groups, signaling ongoing challenges in controlling
Background: Pneumococcal conjugate vaccines (PCVs) that are ten-valent (PCV10) and 13-valent (PCV13) became available in 2010. We evaluated their global impact on invasive pneumococcal disease (IPD) incidence in all ages.
Methods: Serotype-specific IPD cases and population denominators were obtained directly from surveillance sites using PCV10 or PCV13 in their national immunisation programmes and with a primary series uptake of at least 50%.
Article Synopsis
- The PSERENADE project focuses on global surveillance of invasive pneumococcal disease (IPD) to assess the impact of pneumococcal conjugate vaccines (PCV10/13).
- Among 138 countries using PCV10/13 as of 2018, 109 had IPD surveillance systems, with data collected from 76, enabling a comprehensive analysis of 240,639 post-vaccine IPD cases.
- The dataset will aid in understanding the effectiveness of the vaccines across different demographics and vaccination schedules, influencing future immunization policies globally and nationally.
Article Synopsis
- Serotype 1 (ST1) was a major cause of invasive pneumococcal disease (IPD) before the introduction of pneumococcal conjugate vaccines (PCVs), which include ST1 antigen.
- The PSERENADE project analyzed global data on ST1 IPD to assess the impact of PCV10/13 on disease rates, using advanced statistical methods.
- Results showed that after six years of using PCV10/13, there was a 95% reduction in ST1 IPD incidence across all age groups, but there is a need for more data from countries heavily affected by ST1 to improve the findings' applicability.
A case of food-borne botulism occurred in Slovakia in 2015. Clostridium botulinum type A was isolated from three nearly empty commercial hummus tubes. The product, which was sold in Slovakia and the Czech Republic, was withdrawn from the market and a warning was issued immediately through the European Commission's Rapid Alert System for Food and Feed (RASFF).
View Article and Find Full Text PDFSurveillance of pneumococcal diseases in Central and Eastern Europe.
Hum Vaccin Immunother
August 2016
Pneumococcal infection is a major cause of morbidity and mortality worldwide. The burden of disease associated with S. pneumoniae is largely preventable through routine vaccination.
View Article and Find Full Text PDFFactors affecting the success of influenza laboratory diagnosis.
Cent Eur J Public Health
September 2014
Influenza is one of the most common human infectious diseases, and has profound health and economic consequences. The laboratory diag- nosis of influenza virus infections plays an important role in the global surveillance of influenza. Therefore, there is a growing demand for highly sensitive and rapid methods for detecting influenza.
View Article and Find Full Text PDFMany severe diseases of the respiratory tract lead to hospitalisation. These diseases are often caused by viral infections and may cause increased mortality. The most common viral pathogens involved in these cases, which are also associated with significant morbidity and mortality during the influenza seasons are influenza viruses.
View Article and Find Full Text PDFBy application of the real-time PCR we manage to confirm the diagnosis and occurrence of a disease, which is caused by Bordetella pertussis-pertussis. Using this method we have proven the presence of DNA of Bordetella pertussis in the biological materials (nasopharyngeal swabs). The presence of IS481 genome sequence of Bordetella pertussis was confirmed.
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