Publications by authors named "Lucia Luengo-Gutierrez"
Nerve injuries cause permanent neurological disability due to limited axonal regeneration. Injury-dependent and -independent mechanisms have provided important insight into neuronal regeneration, however, common denominators underpinning regeneration remain elusive. A comparative analysis of transcriptomic datasets associated with neuronal regenerative ability revealed circadian rhythms as the most significantly enriched pathway.
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- The regenerative capacity of mammalian peripheral nervous system neurons is limited by slow axonal regeneration after injury, influenced by both the injury itself and external factors like exercise and enriched environments.
- Intermittent fasting (IF) might enhance axonal regeneration, influenced by the gut microbiome and the metabolite indole-3-propionic acid (IPA).
- Research shows that IPA, produced by gut bacteria, is essential for efficient axonal regeneration, promoting recovery of sensory function through immune system involvement, specifically neutrophil chemotaxis.