Publications by authors named "Lucia Garcia-Carracedo"
Neuropathological Heterogeneity of Dementia Due to Combined Pathology in Aged Patients: Clinicopathological Findings in the Vallecas Alzheimer's Reina Sofía Cohort.
Iván Burgueño-García María José López-Martínez Alicia Uceda-Heras Lucía García-Carracedo María Ascensión Zea-Sevilla
J Clin Med
November 2024
Article Synopsis
- Recent research on late-life dementia highlights both neurodegenerative and vascular conditions contributing to the varied symptoms in patients, utilizing the Vallecas Alzheimer's Reina Sofía (VARS) cohort with over 550 participants and associated brain donations.
- The study focused on 167 patients, primarily older women (79%) with an average age of 88, and found a significant presence of the ApoE-e4 gene variant (43%).
- The main findings revealed that 79.6% had Alzheimer's disease, with a high prevalence of other conditions like vascular dementia and Lewy body dementia, and over 71.1% of the patients showed multiple neuropathological findings, indicating the complexity of dementia in this cohort.
Voltage-gated Ca2.1 (P/Q-type) Ca channels play a crucial role in regulating neurotransmitter release, thus contributing to synaptic plasticity and to processes such as learning and memory. Despite their recognized importance in neural function, there is limited information on their potential involvement in neurodegenerative conditions such as Alzheimer's disease (AD).
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