Publications by authors named "Lucia Aa Giannini"
Acta Neuropathol Commun
August 2023
Article Synopsis
- Early-stage pathological features of frontotemporal lobar degeneration (FTLD) due to MAPT variants are understudied, with this research providing insights from three presymptomatic/early-stage cases.
- The study involved quantifying tau burden and neuronal degeneration across multiple brain regions and compared results to intermediate/end-stage cases with the same MAPT variants.
- Findings indicated variability in tau burden by variant type at early stages, but overall, early tau and neuronal degeneration were less severe compared to later stages, with clinical severity strongly correlating with neuronal degeneration.
