Publications by authors named "Lucheng Chang"
Stimulation of melanin synthesis by UVB is mediated by NO/cGMP/PKG cascade targeting PAK4 in vitro.
In Vitro Cell Dev Biol Anim
March 2021
The coat color of mammals is primarily determined by the type, quantity, and distribution of melanin in the skin and hair. As an endogenous gas molecule, nitric oxide (NO) regulates tyrosinase production by modulating the cGMP-dependent protein kinase (PKG) pathway, which enhances melanin synthesis. However, some interrelationships have not been fully elucidated.
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- The study investigates how exosomes and miRNAs, particularly miR-330-5p, regulate pigmentation in skin cells by examining the interactions between keratinocytes (skin cells) and melanocytes (pigment-producing cells).
- Keratinocytes were found to secrete exosomes containing miR-330-5p, which then influenced melanocyte behavior by decreasing melanin production and the expression of the TYR gene, responsible for pigmentation.
- The research highlights a novel mechanism of crosstalk between skin cells that may provide new insights into the regulation of skin pigmentation and potential therapeutic targets.
Distribution and expression of SLC45A2 in the skin of sheep with different coat colors.
Folia Histochem Cytobiol
April 2017
Introduction: To investigate whether the membrane-associated transporter protein SLC45A2 is differentially expressed in the skin of sheep with different coat colors and to determine its correlation with coat color establishment in sheep.
Material And Methods: The expression of SLC45A2 in sheep skin samples with different coat colors was qualitatively and quantitatively analyzed by PCR amplification, RT-PCR, immunohistochemical staining and Western blotting.
Results: A 193-bp SLC45A2 CDS sequence was successfully amplified from sheep skin samples with diverse coat colors.