Publications by authors named "Luce Menudier"
Liver involvement is an unusual yet frequently overlooked dengue complication. Pivotal for an efficient clinical management, the early diagnosis of dengue-associated liver involvement relies on an accurate description of its clinical and biological characteristics, its prognosis factors, its association with severe dengue and its clinical management. We conducted a systematic review by searching PubMed and Web of Science databases for original case reports, cohort and cross-sectional studies reporting the clinical and/or biological features of dengue-associated liver involvement.
View Article and Find Full Text PDFWe developed mathematical models to analyze a large dengue virus (DENV) epidemic in Reunion Island in 2018-2019. Our models captured major drivers of uncertainty including the complex relationship between climate and DENV transmission, temperature trends, and underreporting. Early assessment correctly concluded that persistence of DENV transmission during the austral winter 2018 was likely and that the second epidemic wave would be larger than the first one.
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- - Reunion Island has seen a resurgence of dengue outbreaks since 2018, with increasing severity and intensity, despite decades of low viral circulation.
- - A study conducted from 2018 to 2021 showed a rise in severe dengue cases and pediatric infections, with a notable shift in the dominant serotype from DENV2 to DENV1.
- - The findings suggest dengue is becoming endemic in the region, highlighting the need for health authorities to address the evolving public health implications associated with the disease.
Article Synopsis
- The incidence of dengue cases has surged in the past two decades, particularly influenced by urbanization, with many cases going unnoticed due to asymptomatic infections.
- A 2019 dengue outbreak in La Reunion led to over 18,000 confirmed cases, and a study involving 605 participants found low rates of active infections, but a significant number showed evidence of past infections.
- Research indicated that dengue transmission was localized, with most cases occurring within 100 meters and under a week apart, and environmental factors like housing type and street cleanliness were linked to infection rates, rather than demographic characteristics.
BackgroundWith more than 300 million infections estimated annually worldwide, dengue is the most prevalent arboviral infection. On Reunion Island, after a large outbreak in 1977-78, only limited episodes of viral circulation or sporadic cases were reported till 2015.AimOur objective was to document and report on the circulation of dengue virus after the occurrence of a small outbreak during austral summer 2015/16 and until the large outbreak of 2018.
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