Publications by authors named "Lucas Toshio Ito"
Background: Prior studies suggest that childhood maltreatment is associated with altered hippocampal volume. However, longitudinal studies are currently scarce, making it difficult to determine how alterations in hippocampal volume evolve over time. The current study examined the relationship between childhood maltreatment and hippocampal volumetric development across childhood and adolescence in a community sample.
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- * Researchers analyzed data from 2,511 children and adolescents in Brazil, comparing ADHD biomarkers like polygenic scores, subcortical volumes, and executive function among different risk groups.
- * Findings showed that a risk-informed approach significantly highlighted differences in biomarkers, suggesting this method could improve evaluations for ADHD and potentially other mental disorders.
Attention-Deficit/Hyperactivity Disorder (ADHD) is a neurodevelopmental disorder associated with brain differences in children, but not in adults. A combined evaluation of the regional brain differences could improve statistical power and, consequently, allow the detection of possible effects in adults. Thus, our aim is to verify whether Neuroimaging Association Scores (NAS) are associated with adulthood ADHD and clinical trajectories of the disorder in midlife.
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- Extracellular vesicles (EVs) play a key role in biological processes like cell communication and contain microRNAs (miRNAs) linked to mental health disorders.* -
- The study analyzed miRNA expression in serum EVs from 116 adolescents over two time points to compare those with Major Depressive Disorder, Anxiety disorders, and ADHD to those without psychiatric diagnoses.* -
- While the longitudinal analysis showed no significant results, the cross-sectional findings indicated specific miRNA changes associated with ADHD, MDD, and ANX, highlighting their potential role in mental health. *