Publications by authors named "Lucas Spanaus"
Molecular basis of human nuclear and mitochondrial tRNA 3' processing.
Nat Struct Mol Biol
January 2025
Article Synopsis
- Eukaryotic tRNA precursors need to be processed sequentially to become mature tRNAs, with ELAC2 being essential for processing both nucleus-encoded (nu-tRNAs) and mitochondria-encoded (mt-tRNAs) types.
- ELAC2 can independently process nu-tRNAs, but for most mt-tRNAs, it requires the assistance of TRMT10C and SDR5C1, especially for those without a canonical structure.
- The study reveals that while standard tRNAs are recognized through direct interactions between ELAC2 and the RNA, the processing of noncanonical mt-tRNAs relies on interactions between ELAC2 and the proteins TRMT10C and SDR5C1, highlighting an evolved mechanism for tRNA maturation in
The COVID-19 pandemic continues to spread around the world and remains a major public health threat. Vaccine inefficiency, vaccination breakthroughs and lack of supply, especially in developing countries, as well as the fact that a non-negligible part of the population either refuse vaccination or cannot be vaccinated due to age, pre-existing illness or non-response to existing vaccines intensify this issue. This might also contribute to the emergence of new variants, being more efficiently transmitted, more virulent and more capable of escaping naturally acquired and vaccine-induced immunity.
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