Derivation of Candidate Clinical Decision Rules to Identify Infants at Risk for Central Apnea.

Background And Objectives: Central apnea complicates, and may be the presenting complaint in, bronchiolitis. Our objective was to prospectively derive candidate clinical decision rules (CDRs) to identify infants in the emergency department (ED) who are at risk for central apnea.

Methods: We conducted a prospective observational study over 8 years.

Is the interpretation of rapid antigen testing for respiratory syncytial virus as simple as positive or negative?

Objective: To measure the performance characteristics of an immunochromatographic rapid antigen test for respiratory syncytial virus (RSV) and determine how its interpretation should be contextualised in patients presenting to the emergency department (ED) with bronchiolitis.

Design: Diagnostic accuracy study of a rapid RSV test.

Setting: County hospital ED.

A matched case control study with propensity score balancing examining the protective effect of paracetamol against parentally reported apnoea in infants.

Background: Central apnoea occurs in infants and if not detected leads to death. Central apnoea is a prostaglandin E(2) (PGE2) mediated effect that is susceptible to pharmacologic manipulation in animal models. Paracetamol and ibuprofen are centrally and peripherally acting PGE2 inhibitors, respectively.