Publications by authors named "Lucas S de Oliveira"

The interaction of Plasmodium falciparum-infected red blood cells (iRBCs) with the vascular endothelium plays a crucial role in malaria pathology and disease. KAHRP is an exported P. falciparum protein involved in iRBC remodelling, which is essential for the formation of protrusions or "knobs" on the iRBC surface.

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Article Synopsis
  • Chagas disease, sleeping sickness, and malaria are serious infections caused by protozoan parasites that affect millions globally.
  • In an experiment, synthetic polyalanine peptides were tested for their effectiveness against these parasites, showing that two specific peptides inhibited growth significantly.
  • Structural analysis revealed that one peptide interacts more deeply with cell membranes, suggesting different mechanisms of action, which supports the idea of using these peptides as potential treatments for sleeping sickness.
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Chikungunya virus (CHIKV) is a single-stranded positive RNA virus that belongs to the genus and is transmitted to humans by infected and bites. In humans, CHIKV usually causes painful symptoms during acute and chronic stages of infection. Conversely, virus-vector interaction does not disturb the mosquito's fitness, allowing a persistent infection.

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Many Amazonian fish' reproduction is associated to seasonality and to the conditions of habitat integrity. In a Neotropical floodplain lake of the Amazon region, the temporal structure of ichthyoplankton was investigated and the hypothesis that the density of fish eggs and larvae and the diversity of species vary between two areas with different levels of environmental changes occurred was tested. The sampling occurred monthly between September 2017 and August 2018.

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The calcium ion (Ca) is a ubiquitous second messenger involved in key biological processes in prokaryotes and eukaryotes. In species, Ca signaling plays a central role in the parasite life cycle. It has been associated with parasite development, fertilization, locomotion, and host cell infection.

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Larval ontogeny of the long-whiskered catfish Pimelodus blochii Valenciennes, 1840 is described, providing useful characters for identification and determining the growth pattern throughout its development. Eighty-nine larvae classified in three stages (preflexion, flexion and postflexion) and 30 juveniles were analyzed, totaling 119 individuals. The specimens were collected monthly from January 2013 to May 2019 in the lower Amazon river.

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Chagas disease is caused by the protozoan Trypanosoma cruzi, affecting around 8 million people worldwide. After host cell invasion, the infective trypomastigote form remains 2-4 hours inside acidic phagolysosomes to differentiate into replicative amastigote form. In vitro acidic-pH-induced axenic amastigogenesis was used here to study this step of the parasite life cycle.

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This article presents a proteomic dataset generated from a comparative analysis of the exoproteome of ATCC 15305, 7108 and 9325 strains. The extract of secreted proteins were obtained after incubation of stationary phase cells in BHI medium. All samples were submitted to nano-ESI-UPLC-MS, and the spectrum obtained was processed and analyzed by ProteinLynx Global Server (PLGS), Uniprot and Pedant databases, for identification, annotation and functional classification of proteins.

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