Single Elementary Charge Fluctuations on Nanoparticles in Aqueous Solution.

100 years ago, in 1923, the Nobel prize in physics was awarded for measurement of the unit charge. In addition to a profound impact on contemporary physics, this discovery has reshaped our understanding of charge-based interactions in chemistry and biology, ranging from oxidation and ionization to protein folding and metabolism. In a liquid, the discrete nature of the electric charge becomes prominent at the nanoscale when a charge carrier is exchanged between a molecule or a nanoparticle and the surrounding medium.