ADAM10 isoforms: Optimizing usage of antibodies based on protein regulation, structural features, biological activity and clinical relevance to Alzheimer's disease.

A Disintegrin and Metalloproteinase 10 (ADAM10) is a crucial transmembrane protein involved in diverse cellular processes, including cell adhesion, migration, and proteolysis. ADAM10's ability to cleave over 100 substrates underscores its significance in physiological and pathological contexts, particularly in Alzheimer's disease (AD). This review comprehensively examines ADAM10's multifaceted roles, highlighting its critical function in the non-amyloidogenic processing of the amyloid precursor protein (APP), which mitigates amyloid beta (Aβ) production, a critical factor in AD development.

Plasma ADAM10 Levels and Their Association with Alzheimer's Disease Diagnosis in Older Adults with Fewer Years of Formal Education.

Introduction: Low educational attainment is a potential risk factor for Alzheimer's disease (AD) development. Alpha-secretase ADAM10 plays a central role in AD pathology, attenuating the formation of beta-amyloid peptides and, therefore, their aggregation into senile plaques. This study seeks to investigate ADAM10 as a blood-based biomarker in mild cognitive impairment (MCI) and AD in a diverse group of community-dwelling older adults, focusing on those with limited educational attainment.

The Association of Levels of Mindfulness on the Cognitive Performance of Community-Dwelling, Low-Educated Older Adults From a Middle-Income Country.

Limited information exists on the potential link between levels of mindfulness and cognitive performance in seniors with low education. This cross-sectional study aims to explore the association between mindfulness levels and cognitive performance in older adults with different years of education. Participants were grouped by education levels and assessed for cognitive performance (ACE-R; Digit Span test), levels of mindfulness (Langer Mindfulness Scale-21), and depressive symptoms (Geriatric Depression Scale-15).

Performance of older adults in a digital change detection task: The role of heterogeneous education.

The influence of education on traditional paper-and-pen cognitive assessments is widely reported. However, a minimal amount of evidence is available regarding the role of education in digital tasks. This study aimed to compare the performance of older adults with different educational attainment in a digital change detection task, as well as to relate their performance on the digital task and traditional paper-based tests.

Socio-cognitive mindfulness predicts memory complaint and cognitive performance of older adults with different years of education.

Background: Even though the effect of education on cognitive performance has been widely reported, the relationship between socio-cognitive mindfulness, cognitive performance, and memory complaint among the elderly with heterogeneous educational levels has not yet been investigated.

Aim: This study aimed to analyze the potential relationship between cognitive performance, memory complaint, and socio-cognitive mindfulness in a sample of healthy older adults with different years of education.

Methods: In this quantitative, cross-sectional, observational, and analytical study, participants ( = 68) were assessed with a sociodemographic questionnaire, cognitive performance test (ACE-III), levels of socio-cognitive mindfulness (LSM-21), and memory complaint (Memory Complaint Scale).

Musculoskeletal symptoms in formal and informal caregivers of elderly people.

Objective: to evaluate musculoskeletal symptoms in formal and informal caregivers of elderly people, and check association with personal and work-related factors.

Methods: this is a cross-sectional study. Instruments for assessment were the International Physical Activity Questionnaire, Self-Reporting Questionnaire-20, Borg's effort perception scale and Nordic Musculoskeletal Questionnaire.

Challenges in public perception: highlights from the United Kingdom-Brazil Dementia Workshop.

In July 2019, Belo Horizonte hosted an international workshop for 27 junior researchers, whose participants were from Brazil and the United Kingdom. This three-day meeting organized by the Universidade Federal de Minas Gerais and the University of East Anglia addressed challenges in cognitive impairment and dementia, with particular interest in public perceptions, diagnosis and care management. The purpose of this report is to highlight the outcomes of the above-mentioned workshop regarding the topic of public perceptions (part I).

Burnout syndrome in informal caregivers of older adults with dementia: A systematic review.

Unlabelled: Dementia is a constant concern for the public health system. Also, it impacts family members who provide informal care, often culminating in overload due to the emotional stress and physical distress of caregivers.

Objective: This systematic review aimed to identify the consequences of Burnout Syndrome in informal caregivers of older adults with dementia.