Publications by authors named "Lucas Mitchell"

Purpose: To understand diversity, inclusion, and capacity of genetic counselors (GCs) in Australasia (Australia and New Zealand).

Methods: Individuals with or working toward a GC qualification in Australasia were invited to complete an online survey, between November 2022 and March 2023. Quantitative data were analyzed using descriptive statistics, 1-sample proportion -tests, 2-sample -tests, and χ tests.

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Article Synopsis
  • The study examines how the waist-to-hip ratio (WHR) affects the risk of liver disease and diabetes in individuals with the HFE p.C282Y+/+ genotype from the UK Biobank.
  • It found that a higher WHR significantly increases the risk of liver fibrosis, cirrhosis, liver cancer, and type 2 diabetes, with notably higher hazards for males compared to females.
  • The researchers suggest that reducing central fat could improve health outcomes for these individuals, indicating a need for interventions targeting weight management.
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Objectives: haemochromatosis genetic variants have an uncertain clinical penetrance, especially to older ages and in undiagnosed groups. We estimated p.C282Y and p.

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The use of genomic data in research and genomic information in clinical care is increasing as technologies advance and sequencing costs decrease. Using Rogers' Diffusion of Innovation (DOI) theory as a framework we reviewed recent literature examining publics' current knowledge of, attitude to, and motivation towards health-related genomics in clinical and research settings. The population of interest was described as 'publics' to denote the heterogeneity of 'the public'.

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Article Synopsis
  • - The growing use of genomic sequencing has led to more frequent detection of secondary findings (SF), prompting researchers to create guidelines for managing these findings before starting their studies.
  • - A review analyzed studies from 2010 to 2023 to evaluate the experiences and outcomes of research participants who received actionable SF, identifying that the uptake of SF varied widely from 20% to 97%.
  • - Results showed minimal psychological impact from receiving SF, with most participants valuing the information; this emphasizes the need for careful planning involving genetic health professionals to support participants in the process.
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Objective: To identify and map research into the visibility of LGBTQIA+ people and their relationships in healthcare, with the view to inform future research and practice.

Method: Five databases were systematically searched for published and grey literature. Primary research reporting on visibility of LGBTQIA+ people in healthcare was included.

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The appearance of the seed is an important aspect of consumer preference for cowpea ( [L.] Walp.).

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Cowpea (Vigna unguiculata L. Walp.) is a legume crop that is resilient to hot and drought-prone climates, and a primary source of protein in sub-Saharan Africa and other parts of the developing world.

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Genome resolution of a major QTL associated with the Rk locus in cowpea for resistance to root-knot nematodes has significance for plant breeding programs and R gene characterization. Cowpea (Vigna unguiculata L. Walp.

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Seed size distinguishes most crops from their wild relatives and is an important quality trait for the grain legume cowpea. In order to breed cowpea varieties with larger seeds we introgressed a rare haplotype associated with large seeds at the Css-1 locus from an African buff seed type cultivar, IT82E-18 (18.5 g/100 seeds), into a blackeye seed type cultivar, CB27 (22 g/100 seed).

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The cowpea aphid Koch (CPA) is a destructive insect pest of cowpea, a staple legume crop in Sub-Saharan Africa and other semiarid warm tropics and subtropics. In California, CPA causes damage on all local cultivars from early vegetative to pod development growth stages. Sources of CPA resistance are available in African cowpea germplasm.

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We report the novel synthesis of nanoporous TiO2 nanoparticle ensembles with unique mesoscale morphologies. Constituent nanoparticles evolved into multifaceted assemblies, exhibiting excellent crystallinity and enhanced photocatalytic activity compared with commercial TiO2. Such materials could be exploited for applications, like organic pollutant degradation.

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Highly specific seed market classes for cowpea and other grain legumes exist because grain is most commonly cooked and consumed whole. Size, shape, color, and texture are critical features of these market classes and breeders target development of cultivars for market acceptance. Resistance to biotic and abiotic stresses that are absent from elite breeding material are often introgressed through crosses to landraces or wild relatives.

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With the prevalence of air quality issues in our society, the ability to remove toxic gases from air is a necessity. This work addresses the development of biphasic, nanostructured, organoalkoxysilane-grafted, siliceous materials for use in single pass filters of various types for the removal of acidic and basic gases from humid air. Materials exhibit high single pass capacities for sulfur dioxide, a representative acid-forming gas, or ammonia, a representative basic gas.

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Background: Accurate genetic maps are the cornerstones of genetic discovery, but their construction can be hampered by missing parental genotype information. Inference of parental haplotypes and correction of phase errors can be done manually on a one by one basis with the aide of current software tools, but this is tedious and time consuming for the high marker density datasets currently being generated for many crop species. Tools that help automate the process of inferring parental genotypes can greatly speed the process of map building.

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