Publications by authors named "Lucas Mina"
Article Synopsis
- The endoplasmic reticulum (ER) maintains its balance through molecular regulators that adjust mitochondrial energy use depending on protein folding needs.
- Calnexin plays a role in this process by managing mitochondrial metabolism and their connections to the ER via reactive oxygen species from NADPH oxidase 4 (NOX4).
- A newly discovered interaction between the proteins ERO1⍺ and PERK is crucial for quickly adapting mitochondrial functions to ER stress, enhancing calcium flow between ER and mitochondria, and reducing oxidative stress.
Article Synopsis
- Multiple sclerosis (MS) involves inflammation in the central nervous system (CNS), but the sources and effects of this inflammation are still being studied.
- Reactive oxygen species (ROS) play a critical role in promoting inflammation, generated by certain enzymes in the endoplasmic reticulum (ER), which are part of a balancing act with antioxidants.
- In this research, it was found that Ero1α increases in astrocytes during MS and experimental autoimmune encephalomyelitis (EAE), creating an imbalance in redox enzymes that makes astrocytes more vulnerable to oxidative stress while neurons remain unaffected.
Reactive oxygen species (ROS) are emerging as important regulators of cancer growth and metastatic spread. However, how cells integrate redox signals to affect cancer progression is not fully understood. Mitochondria are cellular redox hubs, which are highly regulated by interactions with neighboring organelles.
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