Publications by authors named "Lucas Mascarin"
Article Synopsis
- * The study examined the role of spinal Neuropeptide Y (NPY) in the pain-relieving effects of 2-PEA, discovering that activation of NPY1 receptors reduced pain while blocking them increased pain.
- * Antinociceptive effects of 2-PEA were reversed by NPY receptor antagonists and diminished by using a neurotoxin that decreased NPY levels, suggesting that the pain relief involves NPY acting through Y1 receptors in the spinal cord.
Monocyte counts are increased during human tuberculosis (TB) but it has not been determined whether () directly regulates myeloid commitment. We demonstrated that exposure to directs primary human CD34 cells to differentiate into monocytes/macrophages. In vitro myeloid conversion did not require type I or type II IFN signaling.
View Article and Find Full Text PDFAims: Rheumatoid arthritis brings great burdens to the patients. In addition to the highly expensive treatment, they are commonly associated with severe side effects. In such context, the research for safe and affordable treatments is needed.
View Article and Find Full Text PDFBackground: Histamine receptors are known to participate in spinal cord nociceptive transmission, and previous studies have suggested that histaminergic receptors are involved in the analgesic effects of morphine. Herein, we investigated the effect of intrathecal injection of histaminergic agonists and antagonists in a model of acute articular inflammation and their interaction with morphine.
Methods: After carrageenan injection in the right knee joint, articular incapacitation was measured hourly, for up to 6 hours, by the paw elevation time during 1-minute periods of stimulated walking.