Publications by authors named "Lucas M Lima"
Importance: High-flow nasal oxygen (HFNO) and noninvasive ventilation (NIV) are commonly used respiratory support therapies for patients with acute respiratory failure (ARF).
Objective: To assess whether HFNO is noninferior to NIV on the rates of endotracheal intubation or death at 7 days in 5 patient groups with ARF.
Design, Setting, And Participants: This noninferiority, randomized clinical trial enrolled hospitalized adults (aged ≥18 years; classified as 5 patient groups with ARF: nonimmunocompromised with hypoxemia, immunocompromised with hypoxemia, chronic obstructive pulmonary disease [COPD] exacerbation with respiratory acidosis, acute cardiogenic pulmonary edema [ACPE], or hypoxemic COVID-19, which was added as a separate group on June 26, 2023) at 33 hospitals in Brazil between November 2019 and November 2023 (final follow-up: April 26, 2024).
High flow nasal catheter therapy versus non-invasive positive pressure ventilation in acute respiratory failure (RENOVATE trial): protocol and statistical analysis plan.
Crit Care Resusc
March 2022
Article Synopsis
- The RENOVATE trial aims to determine if high flow nasal catheter (HFNC) therapy is non-inferior or superior to non-invasive positive pressure ventilation (NIPPV) for treating acute respiratory failure (ARF) across various conditions.
- This multicenter, adaptive randomized controlled trial recruits adult patients from emergency departments, wards, and ICUs, using a Bayesian framework to evaluate outcomes in specific ARF subgroups.
- Key metrics include the rates of endotracheal intubation or death within 7 days, with secondary outcomes looking at longer-term mortality and ICU/IMV-free days, ultimately involving up to 2000 participants.
The First Brazilian Cardiovascular Registry of Atrial Fibrillation: Primary Results of the RECALL Study.
Am Heart J
October 2023
Background: It is estimated that atrial fibrillation (AF) affects approximately 1.5 million people in Brazil; however, epidemiological data are limited. We sought to evaluate the characteristics, treatment patterns, and clinical outcomes in patients with AF in Brazil by creating the first nationwide prospective registry.
View Article and Find Full Text PDFArticle Synopsis
- Respiratory infections, especially caused by viruses like SARS-CoV-2, have become the top infectious disease concern globally, with COVID-19 presenting serious health system challenges due to high morbidity and mortality rates.* -
- Factors affecting the immune response to COVID-19 include age, genetics, nutrition, and environment, but there is currently no specific treatment for the disease.* -
- This study highlights that regular moderate exercise and maintaining vitamin D levels can boost the immune system, reducing inflammation and helping to prevent complications such as the cytokine storm in COVID-19 patients.*
Validation study of the use of the HRVCAM software for the evaluation of heart rate and heart rate variability at rest.
Eur Heart J Digit Health
March 2022
Aims: The existing instruments for assessing heart rate (HR) and heart rate variability (HRV) require contact area. This is difficult to obtain from specific groups of patients and from those moving. The aim of this study was to validate the use of the HRVCam software for measuring HR and HRV in healthy adults.
View Article and Find Full Text PDFImportance: Slower intravenous fluid infusion rates could reduce the formation of tissue edema and organ dysfunction in critically ill patients; however, there are no data to support different infusion rates during fluid challenges for important outcomes such as mortality.
Objective: To determine the effect of a slower infusion rate vs control infusion rate on 90-day survival in patients in the intensive care unit (ICU).
Design, Setting, And Participants: Unblinded randomized factorial clinical trial in 75 ICUs in Brazil, involving 11 052 patients requiring at least 1 fluid challenge and with 1 risk factor for worse outcomes were randomized from May 29, 2017, to March 2, 2020.
Importance: Intravenous fluids are used for almost all intensive care unit (ICU) patients. Clinical and laboratory studies have questioned whether specific fluid types result in improved outcomes, including mortality and acute kidney injury.
Objective: To determine the effect of a balanced solution vs saline solution (0.