Publications by authors named "Lucas Jacob"

Objective: To evaluate cochlear implant speech perception among patients with sporadic inner ear schwannoma who underwent ipsilateral implantation.

Study Design: Retrospective multi-institutional cohort study.

Setting: Eleven tertiary academic medical centers across Germany, Denmark, and the United States.

View Article and Find Full Text PDF
Article Synopsis
  • The study focused on the impact of race and insurance status on high-grade renal trauma (HGRT) among children, analyzing data from a large trauma registry between 2007 and 2020.
  • Out of 341 initially identified pediatric patients with HGRT, differences were observed in the mechanism of injury and presentation age based on race, with African American (AA) patients experiencing more penetrating trauma and younger age at presentation.
  • Insurance status affected the rates of bowel injuries and blood transfusions, and private insurance patients had higher rates of follow-up care, but neither race nor insurance status impacted overall surgical intervention outcomes, post-injury complications, or mortality rates.
View Article and Find Full Text PDF
Article Synopsis
  • - This study compares cochlear implant (CI) outcomes for speech perception in patients with sporadic vestibular schwannoma (VS) treated through observation, radiosurgery, or microsurgery.
  • - Of the 100 patients analyzed, those who underwent microsurgery had poorer speech perception scores compared to those who were observed or treated with radiosurgery, with only 61% achieving open-set speech perception after microsurgery.
  • - The findings suggest that cochlear implants can be beneficial for sporadic VS patients, particularly those managed by observation or radiosurgery, as these groups showed significantly better outcomes in achieving open-set speech perception.
View Article and Find Full Text PDF

Objective: To analyze the outcomes of exoscopic versus microscopic ossicular chain reconstruction (OCR).

Study Design: Retrospective chart review.

Setting: Tertiary care otology-neurotology practice.

View Article and Find Full Text PDF

Objective: Identify if pre-incident aspirin influences severity and outcome of idiopathic sudden sensorineural hearing loss (SSNHL).

Study Design: Retrospective review.

Setting: Tertiary care center.

View Article and Find Full Text PDF

Objective: To analyze the outcomes of exoscopic versus microscopic type 1 tympanoplasty.

Study Design: Retrospective chart review.

Setting: Tertiary care otology-neurotology practice.

View Article and Find Full Text PDF

Genitourinary manifestations are rare in patients with Crohn's disease, and a small percentage of patients will experience enterocutaneous fistulas. Infection is one of the most common complications associated with inflatable penile prosthesis placement, which can be associated with fistula formation. In this report, we present a patient with Crohn's disease who developed an inflatable penile prosthesis infection secondary to an undiagnosed enterocutaneous fistula.

View Article and Find Full Text PDF

Objectives: Evaluate the effect of rurality on newborn hearing screen outcomes in Michigan.

Methods: Patients in the Michigan Department of Health and Human Services (MDHHS) Newborn Hearing Screening database that failed or did not receive their initial screen from 2015 to 2020 were evaluated. Using the U.

View Article and Find Full Text PDF

Objective: To quantify contralateral hearing outcomes after labyrinthectomy for unilateral Ménière's disease (MD).

Study Design: Retrospective case series.

Setting: Tertiary neurotology referral center.

View Article and Find Full Text PDF

Purpose Of Review: Meniere's disease is caused by hydropic changes in the endolymphatic system, and manifests as a collection of vertigo, hearing loss, tinnitus, and aural fullness. Although high-quality clinical practice guidelines exist for the diagnosis and initial management of Meniere's disease, there is no strong consensus for treatment of medically refractory Meniere's disease. This review summarizes treatment options and highlights controversies surrounding surgical treatment of Meniere's disease.

View Article and Find Full Text PDF

The pseudo-tetrasaccharide acarbose, produced by sp. SE50/110, is a α-glucosidase inhibitor used for treatment of type 2 diabetes patients. In industrial production of acarbose, by-products play a relevant role that complicates the purification of the product and reduce yields.

View Article and Find Full Text PDF

The retrosigmoid corridor provides the most broadly applied approach for resection of sporadic vestibular schwannoma. It may be utilized for any size tumor and for patients with intact hearing with the intention of hearing preservation. For larger tumors, the skull base surgeon must weigh the benefits the retrosigmoid approach against those of the translabyrinthine route.

View Article and Find Full Text PDF

Objective: To compare the completeness of resection of vestibular schwannomas using three-dimensional segmented volumetric analysis of pre- and postoperative magnetic resonance imaging (MRI) of patients undergoing supine and semisitting positioning for the retrosigmoid approach.

Study Design: Retrospective chart review.

Setting: Tertiary medical center.

View Article and Find Full Text PDF

Placement of penile prosthesis had been well described in the outpatient setting, however, one barrier to same-day discharge is postoperative urinary retention (POUR). POUR remains a condition encountered during ambulatory surgical procedures and has yet to be characterized in patients undergoing penile prosthesis. We characterized POUR in a cohort of penile prosthesis recipients along with risk factors and management.

View Article and Find Full Text PDF

Background: Dysfunction in the olfactory, auditory, and vestibular systems are commonly seen in aging and are associated with dementia. The impact of sensory loss(es) on cognition is not well understood. Our aim was to assess the relationships between performance on objective multisensory testing and quantify the impact of dysfunction on cognition.

View Article and Find Full Text PDF

Purpose: Micronutrients and their supplementation have been investigated in the development, severity, and treatment of tinnitus. This study aimed to evaluate associations between tinnitus parameters and levels of zinc, manganese, and vitamin B12.

Materials And Methods: This retrospective study analyzed National Health and Nutrition Examination Survey 2011-2012 and 2015-2016 participants aged 20-69 who answered whether they had symptoms of tinnitus in the past year.

View Article and Find Full Text PDF
Article Synopsis
  • Seizures are thought to be caused by an imbalance between excitatory and inhibitory neurons, with traditional views emphasizing excessive excitatory activity as the primary trigger.
  • Recent research using a zebrafish seizure model has investigated this notion, observing both excitatory and inhibitory neuron activity through advanced imaging techniques.
  • The study found that seizures typically start in specific midbrain areas with high excitatory activity and spread to other regions, indicating that while both neuron types are involved, excitatory neurons play a more significant role in initiating seizures.
View Article and Find Full Text PDF

Three novel corynebacterial species were isolated from soil sampled at a paddock in Vilsendorf, North Rhine-Westphalia, Germany. The strains were coccoid or irregular rod-shaped, catalase-positive and pale white to yellow-orange in colour. By whole genome sequencing and comparison of the 16S rRNA genes as well as the whole genome structure, it was shown that all three strains represent novel species of the family , order , class .

View Article and Find Full Text PDF

Objectives: Alveolar soft part sarcoma is a rare subset of soft tissue sarcomas, typically presenting in subjects 15 to 35 years of age. Usual presentation sites are the trunk, extremities, and the head and neck. Subjects younger than 5 years are rarely affected.

View Article and Find Full Text PDF

This case report describes a child who developed Pott's puffy tumor and was treated at the Children's Mercy Hospital in Kansas City. In addition to a discussion of a case, a review of the literature was completed on this topic describing the typical embryology and development of the frontal sinus, and the epidemiology, diagnosis, and treatment of Pott's puffy tumor. The patient was a 23-month-old boy who developed Pott's puffy tumor after recovery from influenza.

View Article and Find Full Text PDF

Unlabelled: INTRODUCTION Evidence suggests overutilization of procedural intervention for renal traumas. The objective of this study was to assess clinical factors associated with procedural intervention for patients presenting to the emergency department (ED) with isolated renal trauma.

Materials And Methods: A United States statewide trauma registry was queried for trauma patients presenting to level I or II trauma centers with isolated renal injuries (Grades I-V) from 2000-2013.

View Article and Find Full Text PDF
Article Synopsis
  • The pSETT4 vector uses the φC31 integrase to integrate into the sp. SE50/110 chromosome for efficient gene cloning.
  • It employs Golden Gate assembly with the BsaI restriction enzyme to enable easy insertion of the gene of interest.
  • The vector includes T4 terminators to ensure proper transcription regulation and can be adapted for use in other systems by swapping out the promoter.
View Article and Find Full Text PDF
Article Synopsis
  • This research aimed to evaluate the effectiveness of an "optimal modeling" technique for patients with residual curvature after penile implant surgery.
  • A study reviewed patients with over 30° of curvature who underwent this technique, comparing them to a similar group that didn't receive the additional correction.
  • Results showed significant improvement in curvature, with 87.5% achieving less than 15° post-treatment, and no complications arose in either group during the follow-up period.
View Article and Find Full Text PDF