Plasma ALS and Gal-3BP differentiate early from advanced liver fibrosis in MASLD patients.

Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is estimated to affect 30% of the world's population, and its prevalence is increasing in line with obesity. Liver fibrosis is closely related to mortality, making it the most important clinical parameter for MASLD. It is currently assessed by liver biopsy - an invasive procedure that has some limitations.

Unveiling the Links Between Peptide Identification and Differential Analysis FDR Controls by Means of a Practical Introduction to Knockoff Filters.

In proteomic differential analysis, FDR control is often performed through a multiple test correction (i.e., the adjustment of the original p-values).

Challenging Targets or Describing Mismatches? A Comment on Common Decoy Distribution by Madej et al.

In their recent article, Madej et al. (Madej, D.; Wu, L.