Diaminomaleonitrile derivatives as new potential antichagasic compounds: a study of structure-activity relationships.

Schiff bases are synthetically accessible compounds that have been used in medicinal chemistry. In this work, 27 Schiff bases derived from diaminomaleonitrile were synthesized in high yields (80-98%). Molecular docking studies suggested that the Schiff bases interact with the catalytic site of cruzain.