Publications by authors named "Lucas Cunha Barbosa"
Glioblastomas (GBM) are aggressive tumors known for their heterogeneity, rapid proliferation, treatment resistance, and extensive vasculature. Angiogenesis, the formation of new vessels, involves endothelial cell (EC) migration and proliferation. Various extracellular matrix (ECM) molecules regulate EC survival, migration, and proliferation.
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- ACE2 is a key component of the renin-angiotensin-aldosterone system (RAAS) that converts angiotensin II into angiotensin (1-7) and serves as the entry point for the SARS-CoV-2 virus, particularly on endothelial cells (EC) found in various human organs.
- The dysfunction of EC due to COVID-19 triggers inflammation and immune cell recruitment, leading to abnormal blood coagulation and contributing to serious complications in infected patients.
- Proposed treatments focus on EC-related therapies, such as anticoagulants and immunomodulators, to manage lung inflammation, coagulation disorders, and improve outcomes in COVID-19 patients, including those with cancer involving ACE2.