Publications by authors named "Lucas Collins"
Article Synopsis
- * This review summarizes existing research on LPD, highlights the lack of validated diagnostic criteria, and discusses the controversial role of progesterone supplementation in treating RPL.
- * There's a need for better assessment tools for LPD and further research to understand its impact on fertility and find effective treatments.
Histone methyltransferases play essential roles in the organization and function of chromatin. They are also frequently mutated in human diseases including cancer. One such often mutated methyltransferase, SETD2, associates co-transcriptionally with RNA polymerase II and catalyzes histone H3 lysine 36 trimethylation (H3K36me3) - a modification that contributes to gene transcription, splicing, and DNA repair.
View Article and Find Full Text PDFIntroduction: Little is known about gender's role in chronic venous insufficiency (CVI). The aim of this study was to evaluate the impact of gender on outcomes of iliac vein stenting(IVS) for CVI.
Methods: 866 patients who underwent vein stenting for CVI at one institution from August 2011 to June 2021 were analyzed via retrospective review.
Article Synopsis
- This study investigates how race influences the outcomes of iliac vein stenting procedures for chronic venous insufficiency, revealing significant disparities across different racial groups.
- Data from 827 patients were analyzed, showing that Asian patients tended to be younger, healthier, and had fewer reinterventions compared to Black patients, who had the highest number of reinterventions and the longest follow-up.
- Despite these differences in demographics and outcomes, the stenting technique and overall changes in venous severity scores were similar across racial groups, indicating a need for further research into the underlying factors contributing to these disparities.
Patients with active venous leg ulcers at the time of iliac vein stenting require more reoperations.
J Vasc Surg Venous Lymphat Disord
November 2022
Article Synopsis
- The study investigated the effectiveness of iliac vein stenting (IVS) in treating patients with active venous leg ulcers (VLU+) compared to those without (VLU-), focusing on reoperation needs and symptom outcomes.
- A total of 872 patients were analyzed, revealing that the VLU+ group had a higher average number of reoperations (1.4) compared to the VLU- group (1.0) and a greater continued need for surgeries among those who underwent reoperation.
- Ulcer healing rates for the VLU+ group improved over time, reaching 59% at 36 months, but recurrence rates increased, indicating ongoing challenges in treatment for this cohort.