Caffeine intake during gestation and lactation causes long-term behavioral impairments in heterogenic mice offspring in a sex-dependent manner.

Growing evidence has indicated a potential association between maternal consumption of caffeine and impaired cognition and behavior in rodent offspring. However, potential sex differences, as well as caffeine-related effects in subsequent generations are still poorly investigated. We aimed to investigate the impact of pre-and/or neonatal exposition to caffeine on the neurodevelopment of male and female mice offspring.

Effects of altrenogest supplementation in late lactation on reproductive performance of primiparous sows.

Genetic selection for hyperprolific sows resulted in higher proportion of low birthweight piglets and greater birthweight variation within the litter, increasing preweaning mortality. There is evidence that altrenogest supplementation improves post-weaning reproductive performance through higher ovulation rates, and increased embryo survival. This study aimed to evaluate the impacts of altrenogest supplementation during the last week of lactation in primiparous sows on subsequent reproductive performance.

Maternal chronic caffeine intake impairs fertility, placental vascularization and fetal development in mice.

Caffeine is commonly consumed by pregnant women to avoid fatigue or as a habit. However, it is not clearly determined its side effects to the conceptuses. This study evaluated placental morphofunctional alterations after maternal chronic caffeine intake and the effects on fetal growth.