On the remarkably different role of salt in the cross-coupling of arylzincs from that seen with alkylzincs.

The role of halide salt additives has been investigated in the Negishi reaction involving aryl zinc reagents. Diarylzincs readily transmetallate to Pd in relatively non-polar media (e.g.

Quantitative affinity electrophoresis of RNA-small molecule interactions by cross-linking the ligand to acrylamide.

We show that the affinity electrophoresis analysis of RNA-small molecule interactions can be made quantifiable by cross-linking the ligand to the gel matrix. Using an RNA-aminoglycoside model system to verify our method, we attached an acryloyl chloride molecule to the aminoglycosides paromomycin and neomycin B to synthesize an acrylamide-aminoglycoside monomer. This molecule was then used as a component in gel polymerization for affinity electrophoresis, covalently attaching an aminoglycoside molecule to the gel matrix.

Higher-order zincates as transmetalators in alkyl-alkyl negishi cross-coupling.

Negishi revisited: higher-order alkyl zincates have been subjected to Negishi coupling with alkyl bromides. For the first time, coupling takes place in straight THF, i.e.