Publications by authors named "Lucas C Guimaraes"
Doxorubicin is one of the most important antitumor drugs used in oncology; however, its cardiotoxic effect limits the therapeutic use and raises concerns regarding patient prognosis. Leucine is a branched-chain amino acid used in dietary supplementation and has been studied to attenuate the toxic effects of doxorubicin in animals, which increases oxidative stress. Oxidative stress in different organs can be estimated using several methods, including catalase expression analysis.
View Article and Find Full Text PDFDoxorubicin is associated with cardiotoxicity, and physical exercise seeks to minimize the toxic effects of doxorubicin through physiological cardiac remodeling, as well as the reduction of oxidative stress, evidenced by previous studies. This study aimed to analyze whether running training before treatment with doxorubicin influences tolerance to physical exertion and cardiotoxicity. Thirty-nine male Wistar rats, aged 90 days and weighing between 250 and 300 g, were divided into 4 groups: Control (C), Doxorubicin (D), Trained (T), and Trained + Doxorubicin (TD).
View Article and Find Full Text PDFArticle Synopsis
- Microorganisms, especially fungi, are crucial for producing valuable compounds necessary for humans, plants, and animals, but isolating and improving them can be time-consuming and costly.
- Proper preservation of these microorganisms is essential to maintain their useful characteristics without needing to start the process over.
- The study aimed to evaluate three methods for conserving potentially toxic fungi (Castellani's method, continuous subculture, and lyophilization) to determine which is most effective for long-term preservation.