Publications by authors named "Lucas Bocquin"
()-Atenolol (()-2-(4-(2-Hydroxy-3-(isopropylamino)propoxy)phenyl)acetamide) has been synthesized in >99% enantiomeric excess () with the use of lipase B from Syncozymes (Shanghai, China), in a kinetic resolution of the corresponding racemic chlorohydrin. A catalytic amount of base was used in deprotonation of the phenol building block. The enantiopurity of the chlorohydrin building block remained unchanged upon subsequent amination to yield the final drug.
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- The study involves creating chiral transition metal complexes using achiral imidazolinium salts and various metals like palladium and gold, which leads to a unique axial chirality in these compounds.
- These complexes are stabilized by metal-carbene bonds, allowing for the effective separation of enantiomers through high-performance liquid chromatography (HPLC), achieving over 99% enantiopurity.
- The research also indicates that while the stability of these complexes varies based on their structure and the metal used, it does not directly determine their effectiveness in inducing enantioselectivity in certain chemical reactions.