Monoclonal antibodies in patients with osteoporosis and renal insufficiency: An updated systematic review and meta-analysis.

Objectives: There are challenges for the treatment of osteoporosis in patients with kidney failure and monoclonal antibodies (MAb) might be a suitable therapy. However, the efficacy and safety of MAb among patients with osteoporosis and renal insufficiency remains unclear.

Methods: We systematically searched PubMed, Embase, and Cochrane Central for studies evaluating the efficacy and safety of the use of MAb in patients with osteoporosis and renal insufficiency.

Correlating Structural and Functional Damage in Glaucoma.

Structural and functional tests are essential for detecting and monitoring glaucomatous damage. However, the correlations between structural and functional tests in glaucoma are complex and faulty, with the combination of both modalities being recommended for better assessment of glaucoma. The objective of this review is to explore investigations from the last 5 years in the field of structure-function correlation in glaucoma that contributed to increment in the understanding of this correlation and have the potential to improve the diagnosis and detection of glaucoma progression.

Influence of Bruch's Membrane Opening Area in Diagnosing Glaucoma With Neuroretinal Parameters From Optical Coherence Tomography.

Purpose: To determine whether the glaucoma diagnostic accuracy of age- and Bruch membrane opening area (BMOA)-adjusted normative classifications of minimum rim width (MRW) and retinal nerve fiber layer thickness (RNFLT) is dependent on BMOA, in a European descent population.

Design: Retrospective, cross-sectional study.

Methods: We included 182 glaucoma patients and 166 healthy controls for the primary study, and 105 glaucoma patients in a second sample used for a replication study.

Outer retinal layer thickness in patients with glaucoma with horizontal hemifield visual field defects.

Background/aims: To determine the effect of glaucoma on outer retinal layer thickness in eyes with horizontal hemifield visual field (VF) defects.

Methods: We conducted a cross-sectional study in glaucomatous eyes with repeatable (in three or examinations) horizontal hemifield VF (programme 24-2) defect defined as: all five nasal VF locations immediately either above or below the horizontal midline abnormal in the pattern deviation plot with p<0.5%; no mirror-image adjacent 5 VF locations abnormal in the pattern deviation plot and no non-edge VF locations in the non-affected hemifield abnormal in the pattern deviation plot with p<1%.

Impact of Head Tilt on Optical Coherence Tomography Image Orientation.

Purpose: Head tilt can have an impact on the orientation of posterior pole images. We conducted this study to determine the effect of head tilt on image orientation measured by the fovea-Bruch's membrane opening (FoBMO) angle with optical coherence tomography (OCT) imaging.

Methods: The study included 56 healthy subjects with mean (range) age of 33 (18 to 61) years.

Protruded retinal layers within the optic nerve head neuroretinal rim.

Purpose: To determine the frequency with which retinal tissues other than the nerve fibre layer, hereafter referred to as protruded retinal layers (PRL), are a component of optical coherence tomography (OCT) neuroretinal rim measurements.

Methods: Ninety healthy (30 White, Black and Japanese, respectively) subjects were included in the study. A radial scan pattern (24 B-scans centred on Bruch's membrane opening [BMO]) was used.

Long-term Outcome of Surgical Treatment for Late Intraocular Lens Dislocation Associated With High Intraocular Pressure: A Case Series.

Purpose: To demonstrate the long-term safety and efficacy of transscleral intraocular lens (IOL) fixation combined with an Ahmed glaucoma drainage device implantation for patients with late IOL dislocation and high intraocular pressure (IOP).

Methods: This is a retrospective report of a series of patients who underwent this combined surgery. The main outcome variables studied were change in visual acuity (VA), IOP, and number of medications compared with preoperative levels.

Effect of flaxseed on choroid-sclera complex thickness and on LDL oxidation in the sclera, choroid and retina of diet-induced hypercholesterolaemic rabbits.

The aim of the present study was to evaluate the effect of flaxseed on choroid-sclera complex thickness and on LDL oxidation in the sclera, choroid and retina of diet-induced hypercholesterolaemic rabbits. New Zealand male albino rabbits (n 21) were divided into two groups: group 1 (G1; n 11), fed a hypercholesterolaemic diet, and group 2 (G2; n 10), fed a hypercholesterolaemic diet enriched with flaxseed flour. The serum concentrations of total cholesterol (TC), LDL-cholesterol (LDL-C), HDL-cholesterol, TAG and fasting blood glucose were determined at the start of the experiment and on the day of killing (8th week).