Publications by authors named "Lucas A Pessoa"
Article Synopsis
- Snake venoms, particularly from the genus Bothrops, are responsible for most snakebites in Central and South America, causing severe local and systemic effects, including potential permanent disabilities.
- This study examined how venoms from 19 Bothrops species in Brazil affect the complement system, revealing that these venoms can activate the classical complement pathway without prior antibody sensitization.
- The activation of the complement system by Bothrops venoms leads to the production of inflammatory molecules, which could exacerbate the effects of envenomation and facilitate the spread of other harmful venom components in the human body.
The genus Bothrops spp. is responsible for 90% of envenomation by snakes in Brazil, and the standard treatment for snakebites is the antivenom therapy. The anti-bothropic serum produced by Butantan Institute is prepared by the hyperimmunization of horses with a pool of venoms from Bothrops alternatus, Bothrops jararaca, Bothrops jararacussu, Bothrops moojeni and Bothrops neuwiedi.
View Article and Find Full Text PDF