Design and implementation of the first proton beam transport line in VEGA-3 Petawatt laser system.

Laser-Plasma ion acceleration is acquiring importance on a daily basis due to incipient applicability in certain research fields. However, the energy and divergence control of these brilliant sources can be considered a bottleneck in the development of some applications. In this work, we present the commissioning of a compact proton beamline based on a triplet of quadrupoles dedicated to focus and collect short and energetic pulses, open to the user community.

Changes in 24-hour blood pressure profile after 12 weeks of dapagliflozin treatment in patients with diabetic kidney disease: an Italian multicenter prospective study.

Background: Sodium-glucose cotransporter 2 inhibitors (SGLT2i) lower ambulatory blood pressure (ABP) in patients with type 2 diabetes mellitus; whether the same holds true in diabetic kidney disease (DKD) is unknown. This information is critical to the knowledge of mechanisms of nephroprotection and safety of this therapy.

Methods: This multicenter prospective study evaluates the changes in ABP after 12 weeks of dapagliflozin 10 mg/day in a cohort of patients with type 2 DKD and glomerular filtration rate (GFR) >25 mL/min/1.

A Platform for Ultra-Fast Proton Probing of Matter in Extreme Conditions.

Recent developments in ultrashort and intense laser systems have enabled the generation of short and brilliant proton sources, which are valuable for studying plasmas under extreme conditions in high-energy-density physics. However, developing sensors for the energy selection, focusing, transport, and detection of these sources remains challenging. This work presents a novel and simple design for an isochronous magnetic selector capable of angular and energy selection of proton sources, significantly reducing temporal spread compared to the current state of the art.

Metabolic Associated Fatty Liver Disease in Children and Adolescents: Mechanisms of a Silent Epidemic and Therapeutic Options.

Non-alcoholic fatty liver disease (NAFLD) is now identified as a hepatic sign of metabolic syndrome and is the most frequent cause of chronic liver disease in all ages. It is assumed that a genetic predisposition associated with epigenetic factors participates in the evolution of this condition. Visceral obesity and insulin resistance (IR) have always been considered the most important causative factors of Metabolic Syndrome (MetS) and NAFLD, but currently, the interaction between genetic heritage and environmental factors is increasingly considered fundamental in the genesis of metabolic disorders associated with NAFLD.

The Expanding Phenotype of ZTTK Syndrome Due to the Heterozygous Variant of Gene Focusing on Liver Involvement: Patient Report and Literature Review.

Zhu-Tokita-Takenouchi-Kim (ZTTK) syndrome, an intellectual disability syndrome first described in 2016, is caused by heterozygous loss-of-function variants in . Haploinsufficiency in may affect multiple genes, including those involved in the development and metabolism of multiple organs. Considering the broad spectrum of functions, it is to be expected that pathogenic variants in this gene can cause a wide spectrum of clinical symptoms.

The Role of the GH/IGF1 Axis on the Development of MAFLD in Pediatric Patients with Obesity.

The anomalies of the Growth Hormone (GH)/Insulin-like Growth Factor-1 (IGF1) axis are associated with a higher prevalence of Metabolic Associated Fatty Liver Disease (MAFLD) and with a more rapid progression towards fibrosis, cirrhosis, and end-stage liver disease. A total of 191 adolescents with obesity [12−18 years] were consecutively enrolled between January 2014 and December 2020 and underwent liver biopsy to diagnose MAFLD severity. In all patients GH, IGF1 and Insulin-like Growth Factor-Binding Protein 3 (IGFBP3) were measured.

Control of the Two-photon Visual Process in ex vivo Retinas and in Living Mice.

Palcewska et al. first demonstrated near infrared (NIR) visual response in human volunteers upon two-photon absorption (TPA), in a seminal work of 2014, and assessed the process in terms of wavelength- and power-dependence on murine ex-vivo retinas. In the present study, ex-vivo electroretinography (ERG) is further developed to perform a complete characterization of the effect of NIR pulse duration, energy, and focal spot size on the response.

Angular-Resolved Thomson Parabola Spectrometer for Laser-Driven Ion Accelerators.

This article reports the development, construction, and experimental test of an angle-resolved Thomson parabola (TP) spectrometer for laser-accelerated multi-MeV ion beams in order to distinguish between ionic species with different charge-to-mass ratio. High repetition rate (HHR) compatibility is guaranteed by the use of a microchannel plate (MCP) as active particle detector. The angular resolving power, which is achieved due to an array of entrance pinholes, can be simply adjusted by modifying the geometry of the experiment and/or the pinhole array itself.

Non-Invasive Diagnostic Test for Advanced Fibrosis in Adolescents With Non-Alcoholic Fatty Liver Disease.

Introduction: Non-alcoholic fatty liver disease (NAFLD) is a multifaceted disease that includes a wide spectrum of liver damage. The presence and the degree of fibrosis are considered important factors for the prognosis of NAFLD and in predicting the risk of developing cirrhosis. Our aim was to evaluate the usefulness of four fibrosis scores (aspartate aminotransferase/Platelet Index [APRI], FIB-4, NAFLD Fibrosis Score [NFS], and Hepamet) in predicting different degrees of fibrosis among children with biopsy-proven NAFLD.

Multimode single-pass spatio-temporal squeezing.

We present a single-pass source of broadband multimode squeezed light with potential application in quantum information and quantum metrology. The source is based on a type I parametric down-conversion (PDC) process inside a bulk nonlinear crystal in a non-collinear configuration. The generated squeezed light exhibits a spatio-temporal multimode behavior that is probed using a homodyne measurement with a local oscillator shaped both spatially and temporally.

Off-axis spiral phase mirrors for generating high-intensity optical vortices.

In this work, we present a novel, to the best of our knowledge, and practical method for generating optical vortices in high-power laser systems. Off-axis spiral phase mirrors are used at oblique angles of incidence in the beam path after amplification and compression, allowing for the generation of high-power optical vortices in almost any laser system. An off-axis configuration is possible via modification of the azimuthal gradient of the spiral phase helix and is demonstrated with a simple model using a discrete spiral staircase.

Characterisation and Modelling of Ultrashort Laser-Driven Electromagnetic Pulses.

Recent advances on laser technology have enabled the generation of ultrashort (fs) high power (PW) laser systems. For such large scale laser facilities there is an imperative demand for high repetition rate operation in symbiosis with beamlines or end-stations. In such extreme conditions the generation of electromagnetic pulses (EMP) during high intense laser target interaction experiments can tip the scale for the good outcome of the campaign.

Enhanced relativistic-electron beam collimation using two consecutive laser pulses.

The double laser pulse approach to relativistic electron beam (REB) collimation in solid targets has been investigated at the LULI-ELFIE facility. In this scheme two collinear laser pulses are focused onto a solid target with a given intensity ratio and time delay to generate REBs. The magnetic field generated by the first laser-driven REB is used to guide the REB generated by a second delayed laser pulse.

A promising medium-term follow-up of pediatric sclerosing cholangitis: Mild phenotype or early diagnosis?

Aim: Sclerosing cholangitis (SC) is a chronic cholestatic liver disease that is being increasingly diagnosed in childhood. The long-term course and prognosis of pediatric SC are poorly described.

Methods: We reviewed data of pediatric SC patients, followed in two referral centers, during a period of up to 20 years.